No registrations found.
ID
Source
Brief title
Health condition
Intraoperative cardiac monitoring, left ventricular function
Sponsors and support
Intervention
Outcome measures
Primary outcome
Is it possible to reconstruct intraoperative left ventricular end-systolic pressure-volume relations from a combination of non-invasive finger arterial blood pressure measurements and transesophageal echocardiography in patients undergoing surgery?
Secondary outcome
1. What is the relation of dicrotic notch pressure in the aortic pressure curve to beat average pressure?
2. Loading changes to construct the end systolic pressure-volume relation are commonly induced by reducing preload using inferior vena cava compression. Does increasing afterload using phenylephrine-induced vasoconstriction provide an alternative for inferior vena cava compression?
Background summary
In this study we will investigate a method combining transoesophageal echocardiography and non-invasive finger arterial blood pressure waveforms to non-invasively construct pressure-volume (P-V) loops to describe the end-systolic pressure-volume relations in the heart. This may provide a method to obtain more insight on cardiac contractile function and the interaction of the heart with the vasculature during surgery.
Study objective
Is it possible to construct intraoperative left ventricular end-systolic pressure-volume relations from a combination of non-invasive finger arterial blood pressure measurements and transoesophageal echocardiography in patients undergoing surgery?
Study design
All measurement will take place in the operating room during surgery.
Intervention
Besides standard intraoperative monitoring, patients will receive the following:
1. Transoesophageal echocardiography;
2. Continuous noninvasive finger blood pressure measurements using the Nexfin;
3. Inferior Vena cava occlusion for 15 seconds;
4. Administration of Fenylephrine intravenously.
Afdeling anesthesiologie
Catharina Ziekenhuis Eindhoven
Eindhoven
The Netherlands
arthur.bouwman@catharinaziekenhuis.nl
Afdeling anesthesiologie
Catharina Ziekenhuis Eindhoven
Eindhoven
The Netherlands
arthur.bouwman@catharinaziekenhuis.nl
Inclusion criteria
1. Patients scheduled for:
A. Open abdominal surgery via laparotomy;
B. Cardiac surgery, Coronary Artery Bypass Graft.
2. Age 18-75 years;
3. Informed consent.
Exclusion criteria
Group A specific:
1. Known / documented cardiac disease;
2. ECG / echocardiography abnormalities.
All subjects group A + B:
1. Contraindications for TEE;
2. Contraindications for arterial line;
3. Contraindications for administration of phenylephrine.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2800 |
| NTR-old | NTR2941 |
| Other | VUmc department of Anesthesiology : ANES 2011/01 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |