No registrations found.
ID
Source
Health condition
Colorectal, neoplasia, adenomas, Colonoscopy, Imaging, Detection, classification
Dutch: colon, neoplasie, adenomen, coloscopie, imaging, detectie
Sponsors and support
Intervention
Outcome measures
Primary outcome
Number of adenomas detected by ETMI versus conventional colonoscopy.
Secondary outcome
1. Number of adenomas detected by HRE versus conventional colonoscopy;
2. Miss rate of HRE as followed by AFI (additional yield of AFI);
3. Accuracy of NBI and AFI in discriminating non-neoplastic from neoplastic lesions (Kudo classification and color)
Background summary
Colorectal adenomas are being missed by standard colonoscopy in about 22%. New imaging techniques try to reduce miss rates.
Endoscopic Tri-Modal Imaging (ETMI) incorporates (1) autofluorescence imaging and (2) high resolution endoscopy for detection, and (3) narrow band imaging for classification.
This study compares adenoma detection rates of ETMI with standard colonoscopy and evaluates the use of AFI and NBI for correct endoscopic diagnosis.
Study objective
Endoscopic Tri-Modal Imaging increases the detection rate of colorectal adenomas compared to conventional colonoscopy.
Intervention
ETMI tandem colonoscopy: High resolution endoscopy (HRE) followed by autofluorescence imaging (AFI).
Conventional colonoscopy: Standard resolution colonoscopy followed by standard resolution colonoscopy.
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Inclusion criteria
Patients (>18 years) undergoing colonoscopic surveillance because of:
a. history of adenomatous polyps.
b. history of CRC.
c. Hereditary Non-Polyposis Colorectal Cancer
d. family history of CRC/adenomas
Exclusion criteria
1. Poor bowel preparation;
2. Familial Adenomatous Polyposis, attenuated FAP, MYH associated polyposis or hyperplastic polyposis;
3. History of inflammatory bowel disease;
4. Presence of conditions precluding histological sampling of the colon (e.g. coagulation disorders, anticoagulant therapy).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1010 |
| NTR-old | NTR1039 |
| Other | : |
| ISRCTN | ISRCTN64206478 |