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ID
Source
Health condition
THC, cannabis, false memories, dissociation, mock crime
valse herinneringen, dissociatie,mock misdaad
Sponsors and support
Intervention
Outcome measures
Primary outcome
spontaneous and suggestion-based false memories
Secondary outcome
dissociative states and traits
Background summary
Rationale: False memories refer to memories of events/details that did not occur. False memories frequently occur spontaneously but can also be elicited through suggestion. Legal cases have shown that eyewitnesses and innocent suspects can falsely remember to have seen non-existing details of a crime or falsely confess to have committed a crime due to suggestive interrogation tactics of the police. Such false memories can lead to wrongful convictions. Eyewitnesses and suspects are often under the influence of cannabis but little knowledge exists whether their drugged state makes them more vulnerable to spontaneous or suggestion-induced false memories. From a practical perspective, examining this issue is highly relevant as cannabis is the most widely used drug in the world. Demonstrations of drug-induced false memories may be extremely relevant in the courtroom and in forensic examinations.
Objective: The current project will examine the impact of cannabis intoxication on susceptibility to false memories and dissociation and assess whether such drug-induced experiences depend on an underlying dissociative state or trait. Individual factors of potential influence on false memory (such as attention, compliance) and subjective experience will also be assessed.
Study design: Acute and delayed influences of cannabis on false memory formation will be assessed in a double-blind, placebo-controlled study in occasional cannabis users, using a virtual reality (VR) eyewitness and a perpetrator scenario. The order of treatments and scenarios will be counterbalanced across participants.
Study population: Sixty-four healthy, occasional cannabis users, aged 18-40.
Intervention: Placebo and cannabis vapor (300 μg THC/kg bodyweight)
Main study parameters/endpoints: Spontaneous and suggestion-based false memories will be assessed by using established false memory paradigms (associatively-related word lists, misinformation paradigm). Dissociative states and traits will be assessed using both established self-report and clinician-administered measures.
Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Participants will inhale placebo and cannabis vapor and be exposed to two distinct mock crime scenarios on two separate occasions, each followed by an immediate and a one-week follow-up assessment, including measures of true and false memory and dissociative states and traits.
Study objective
Cannabis intoxication will increase sensitivity to suggested and spontaneous false memories during interrogations
Study design
immediate (after administration of cannabis/placebo) and delayed (one week after administration)
Intervention
300μg THC/kg bodyweight
Postbus 616
Maastricht 6200 MD
The Netherlands
+31 43 3883590
l.kloft@maastrichtuniversity.nl
Postbus 616
Maastricht 6200 MD
The Netherlands
+31 43 3883590
l.kloft@maastrichtuniversity.nl
Inclusion criteria
• Occasional cannabis users
• Age between 18 and 40 years
• Free from psychotropic medication
• Good physical health as determined by medical examination and laboratory analysis
• Absence of any major medical, endocrine and neurological condition
• Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2
• Written Informed Consent
• Good knowledge and understanding of the English language (at least 5 years of English language education)
Exclusion criteria
• History of drug abuse (other than the use of cannabis) or addiction (determined by the medical questionnaire, drug questionnaire and medical examination)
• Pregnancy or lactation (pregnancy test, if needed)
• Hypertension (diastolic> 90; systolic> 140)
• Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination)
• Liver dysfunction
• (Serious) side effects due to previous cannabis consumption
• History of cardiac dysfunctions (arrhythmia, ischemic heart disease,…)
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6494 |
| NTR-old | NTR6682 |
| CCMO | NL60303.068.16 |
| OMON | NL-OMON45359 |