No registrations found.
ID
Source
Brief title
Health condition
Subfertility/infertility in women with advanced maternal age.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Ongoing pregnancy rate.
Secondary outcome
Time to pregnancy, clinical pregnancy rate, pregnancy outcome, implantation rate.
Background summary
A double-blind randomized controlled trial is conducted to determine whether IVF/ICSI combined with PGS in patients with advanced maternal age, i.e. women between 35 and 40 years of age, is a cost-effective alternative compared to IVF/ICSI without PGS.
Patients are allocated at random to one of two treatment arms:
IVF/ICSI with PGS (selection of embryos based on normal number of studied chromosomes)
or IVF/ICSI without PGS (selection of embryos based on morphology). Primary outcome is ongoing pregnancy. Secondary outcomes are time to pregnancy, clinical pregnancy rate, pregnancy outcome and implantation rate.
Study objective
To determine whether IVF/ICSI combined with PGS in patients with advanced maternal age, i.e. women between 35 and 41 years of age, is a cost-effective alternative compared to IVF/ICSI without PGS.
Study design
N/A
Intervention
Patients are allocated at random to one of two treatment arms: IVF/ICSI with PGS (selection of embryos based on normal number of studied chromosomes) or IVF/ICSI without PGS (selection of embryos based on morphology). A maximum of two embryos will be transferred, according to the ESHRE-guidelines. In both treatment arms three treatment-cycles will be offered.
P.O. Box 22660
Sebastiaan Mastenbroek
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5663090
S.Mastenbroek@amc.uva.nl
P.O. Box 22660
Sebastiaan Mastenbroek
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5663090
S.Mastenbroek@amc.uva.nl
Inclusion criteria
Women between 35 and 41 years of age, undergoing IVF (in vitro fertilization) or ICSI (intracytoplasmatic sperm injection).
Exclusion criteria
N/A
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL56 |
| NTR-old | NTR84 |
| Other | : ZON-MW 945-03-013 |
| ISRCTN | ISRCTN76355836 |