No registrations found.
ID
Source
Brief title
Health condition
kidney transplant recipients
niertransplantatie patiënten
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main parameter to be assessed in the current study is the frequency of donor-specific memory B cells as determined by a novel ELISPOT based technique. Furthermore, donor-specific antibody levels will be determined by CDC and Luminex techniques.
Secondary outcome
The secondary study parameters are clinical parameters. The transplant function at 6 and 12 months will be determined by the estimated Glomerular Filtration Rate (eGFR), calculated by the Modification of Diet in Renal Disease (MDRD) formula. Furthermore, the occurrence of cellular and antibody mediated rejection within the first year after transplantation will be recorded.
Study objective
The presence of a broadly reactive anti-donor specific memory B cell compartment is a risk factor for an accelerated memory response after transplantation.
Study design
Peripheral blood (30 ml per time point) will be drawn by venapuncture at 3 time points (pre-transplant, at 3 and 6 months post-transplantation). Clinical follow-up will be performed up to 1 year after transplantation. In case of a living donor transplant, 30 ml of peripheral blood will be drawn from the kidney donor once before the explantation.
Intervention
N/A
Leiden University Medical Center
Albinusdreef 2
Leiden 2333 ZA
The Netherlands
s.heidt@lumc.nl
Leiden University Medical Center
Albinusdreef 2
Leiden 2333 ZA
The Netherlands
s.heidt@lumc.nl
Inclusion criteria
Patients who will undergo a kidney retransplant and, if applicable, their living kidney donor
Exclusion criteria
Hepatitis C or HIV seropositive individuals
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4553 |
| NTR-old | NTR4695 |
| Other | NL42616.058.12 : P13.025 |