No registrations found.
ID
Source
Brief title
Health condition
Urinary tract infections, urosepsis, acute pyelonefritis, acute prostatitis.
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Primary hospital admission rate.
- Secondary hospital admission rate defined as the percentage of patients who need to be hospitalized after initially being treated at home.
Secondary outcome
- Total number of hospitalization days over a 3-month follow-up
- 30-day and 90-day mortality rate
- Intensive Care Unit admission rate
- Hospitalization costs during 3-month follow-up
- Patients’ satisfaction with application of the PRACTICE
- Clinical- and microbiological cure rate
Study objective
Introduction of the PRACTICE into clinical practice leads to lower hospitalization rates without compromising clinical outcome, and lower medical costs.
Study design
Day 0, 2-4, 24-32 and 84-98.
Intervention
Use of the PRACTICE to guide physicians, summing the points for each characteristic: age in years (females age-10); nursing home resident +10; malignancy +30; liver cirrhosis +20; congestive heart failure +10; cerebrovascular disease +10; renal disease +10; altered mental status +20; respiratory rate ¡Ý 30/min +20; systolic blood pressure <90 mmHg +20;
pulse rate >124/min +10; temperature >39.9 C +15. Recommendations: <75 points: strongly recommendation towards home-based management; 75-100 points: consider home-based management; >100 points: strongly recommendation towards hospital admission.
Dept. of Infectious Diseases, C5P
PO Box 9600
J.E. Stalenhoef
Leiden 2300 RC
The Netherlands
J.E. Stalenhoef@lumc.nl
Dept. of Infectious Diseases, C5P
PO Box 9600
J.E. Stalenhoef
Leiden 2300 RC
The Netherlands
J.E. Stalenhoef@lumc.nl
Inclusion criteria
1. Competent patient aged 18 years or above;
2. One or more symptom(s) suggestive of urinary tract infection (dysuria, frequency or urgency*; perineal or suprapubic pain; costo-vertebral tenderness or flank pain);
3. Fever(ear or rectal temp of 38.2 C or higher, or axillary temp of 38 C or higher), or history of feeling feverish with shivering or rigors in the past 24 hours;
4. Positive urine nitrate test and/or leucocyturia as depicted by positive leukocyte esterase test or microscopy.
Exclusion criteria
1. Known allergy to fluoroquinolones;
2. Female patients who are pregnant or lactating;
3. Patients with known polycystic kidney disease;
4. Patients on permanent renal replacement therapy (hemodialysis or peritoneal dialysis);
5. Patients with history of kidney transplantation;
6. Residence outside country of enrolment;
7. Inability to speak or read Dutch;
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4340 |
| NTR-old | NTR4480 |
| CCMO | NL35220.058.11 |
| OMON | NL-OMON41359 |