No registrations found.
ID
Source
Brief title
Health condition
ARDS, COVID19
Sponsors and support
Intervention
Outcome measures
Primary outcome
Identification of specific CLE patterns of the alveolar compartment in invasively ventilated COVID 19 patients
Secondary outcome
Description of how CLE patterns change over time within the same patients, Descriptive correlation of CLE patterns with Chest CT, lung ultrasound, cytology and histology (when available), Time of procedure, Proportion of successful imaging.
Background summary
Acute respiratory distress syndrome (ARDS) is an infrequent but severe complication of COVID 19. The clinical syndrome of ARDS includes a heterogeneous group of patients with varying underlying pathophysiology. The innovative probe-based imaging techniques ‘Confocal Laser Endomicroscopy’ (CLE) is a high-resolution optical technique that, combined with conventional bronchoscopy, has been found to provide real-time, near-histology information about the alveolar compartment. We aim to describe different CLE characteristics of ARDS patients.
Study objective
CLE provides real-time and high detailed information about the characteristics of the alveolar compartment in mechanically ventilated COVID19 patients.
Study design
24 hours of follow up after CLE procedure
Inclusion criteria
- ≥18 years of age
- Non-resolving acute respiratory failure mandating a standard diagnostic bronchoscopy with bronchoalveolar lavage
Exclusion criteria
- Inability and willingness to provide informed consent by family-members
- Patients on extra corporal membrane oxygenation (ECMO)
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9281 |
| Other | METC AMC : 2020_294 |