No registrations found.
ID
Source
Brief title
Health condition
TEA, Cardiac Effects, One-Lung ventilation
Sponsors and support
Laarbeeklaan 101
1090 Jette
Laarbeeklaan 101
1090 Jette
Intervention
Outcome measures
Primary outcome
The use of TEA in patients undergoing Thoracic surgery.
Secondary outcome
The use of TEA in patients with cardiac failure.
Background summary
We aim to evaluate the effects of thoracic epidural analgesia on the heart function in human, both during general anesthesia and mechanical ventilation during major abdominal or thoracic surgery or during one-lung ventilation.
Eighty patients provided an 80% power to detect a two-tailed difference of 10% in echocardiographic parameters before and after TEA with an รก error of 5% based on an expected standard deviation of 20%.
Four different groups of patients will be studied. All these studies will be performed after approval by the Ethical Commission of the Universitair Ziekenhuis Brussel and written, informed consent of the patients.
Study I: Haemodynamic effects on normal lung-ventilation.
Study II: The effects on two and one-lung ventilation.
Study III: The effects of position during OLV.
Study IV: The effects of right versus left one-lung ventilation in supine position.
Study objective
We aim to evaluate the effects of thoracic epidural analgesia on the heart function in human, both during general anaesthesia and mechanical ventilation during major abdominal or thoracic surgery or during one-lung ventilation.
Study design
1. After intubation;
2. After loading of the TEA;
3. After each sequence of TLV and OLV.
Intervention
Registration of images and measurements with TEE.
Veerle Mossevelde, van
Brussels 1090
The Netherlands
+32 (0)2 4763134
veerle.vanmossevelde@uzbrussel.be
Veerle Mossevelde, van
Brussels 1090
The Netherlands
+32 (0)2 4763134
veerle.vanmossevelde@uzbrussel.be
Inclusion criteria
1. >18 years;
2. Elective abdominal surgery;
3. Lung surgery with TEA.
Exclusion criteria
1. <18 years;
2. Patients with altered heart, renal or lung function.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3494 |
| NTR-old | NTR3640 |
| Other | MEC UZ BRussel : 2012/143 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |