No registrations found.
ID
Source
Brief title
Health condition
Bacterial infections
Sponsors and support
Intervention
Outcome measures
Primary outcome
PK-PD target attainment of 50%T>MIC during the first 24 hours of therapy
Secondary outcome
50%T>MIC after 24-48 hours of therapy
PK-PD target attainment of 100%T>MIC during the first 24 hours of therapy
To compare ceftazidime exposure at 24 hours and 24-48 hours after start of treatment between three different renal function groups in terms of AUC and Cmin
Clinical outcome
Background summary
Prospectively investigate whether ceftazidime, in the currently recommended dosing regimen, results in the PK/PD target attainment defined as 50%T>MIC in the first 24 hours of treatment for adult patients on general wards with adequate and impaired renal function receiving regular and recommended reduced doses of ceftazidime.
Study objective
Exploratory study prospectively investigating (validating) the currently recommended dosing regimen of ceftazidime.
Study design
Thee venapunctures in a time period of 48 hours
Intervention
Three venapunctures
Suzanne L. de Vroom
0031 (0)6 29189028
s.l.devroom@amc.uva.nl
Suzanne L. de Vroom
0031 (0)6 29189028
s.l.devroom@amc.uva.nl
Inclusion criteria
Receiving ceftazidime therapy intravenous (iv) as part of standard care
Age ≥ 18 years
Admitted to a general ward of Amsterdam UMC - location AMC
Informed consent is obtained
Exclusion criteria
Renal replacement therapy during treatment with ceftazidime
Patients admitted to the intensive care unit (ICU)
Severely burned patients, defined as a burned surface ≥ 10%
Patients with cystic fibrosis
Informed consent is not obtained
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7864 |
| Other | METC AMC : METC 2019_159 |