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ID
Source
Brief title
Health condition
Obesity, Diabetes Mellitus
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Neural activation in response to tasting sweet and sour solutions under high and low cognitive load measured with fMRI on time point 1 (study day)
2. Taste intensity and hedonic value ratings of the sweet and sour solutions under high and low cognitive load measured with 5-point Likert scale on time point 1
Secondary outcome
1. Performance on the Stroop task (to measure attentional control) measured at time point 1
2. BMI measured at time point 1
3. Responses on the mobile Approach-Avoidance task (AAT) measured on the five days following the study day on time point 1
Background summary
Rationale:
People pay less and less attention to their meals, often engaging in other activities simultaneously. Since mental capacity is limited, this leaves less room for processing of sensory information such as taste. In this ongoing research program, we test the hypothesis that mental load, induced by concurrent tasks or concerns, interferes with reward processing from consumption. Because people strive to obtain pleasure from the goods they consume, they may overconsume to up-regulate hedonic value. Overconsumption is the main driver of overweight and obesity.
Objective:
The present fMRI study aims to investigate the effect of cognitive load on the neural processing of sweet and sour tastes. In particular, the aim is to disentangle the effects of cognitive load on the perceived intensity and hedonic value of taste stimuli. Furthermore, we aim to examine individual differences of this effect related to BMI and attentional control capacity and explore how these differences relate to real life food motivations.
Study design:
Observational study consisting of one lab visit including an fMRI session and a five-day follow-up by means of short questions and tasks on a mobile app.
Study population:
The study will include 60 (+10 pilot participants) healthy male and female volunteers in equal gender proportions, between the age of 18 and 45 years old.
Main study parameters/endpoints:
Neural activation as measured by fMRI and perceived taste intensity and hedonic value in response to tasting sweet and sour solutions under high and low cognitive load.
Study objective
-Cognitive load will negatively impact taste intensity perception and related brain activation
-Cognitive load will not impact hedonic value and related brain activation
Study design
1
Inclusion criteria
• Healthy (self-reported)
• Right-handed
• Between 18 and 45 years old.
• Having given their written informed consent
• BMI between 18.5-30 kg/m2
Exclusion criteria
• Having a history of or current alcohol consumption > 28 units per week
• Daily smoking
• Suffering from cold symptoms
• Having a history of medical or surgical events that may significantly affect the study
outcome, such as metabolic or endocrine disease, or any gastro-intestinal disorder
• Mental or physical status that is incompatible with the proper conduct of the study
• Not having a general practitioner
• Participation in any other clinical trial during this study.
• Common MRI exclusion criteria, including
o Claustrophobia
o Presence of metal in body incompatible with MRI scanning
o Pacemaker
o Being pregnant.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL9327 |
| Other | METC Leiden-Den Haag-Delft : P19.112 |