No registrations found.
ID
Source
Brief title
Health condition
Brachial plexus injury
Sponsors and support
Intervention
Outcome measures
Primary outcome
Percentage of muscle fattening of the m. biceps brachii.
Secondary outcome
1. Elbow flexion stength in Newton and MRC classification;
2. Goutallier score of muscle fatty degeneration;
3. Quality of life questionnaires.
Background summary
A brachial plexus injury is the most severe nerve injury of the extremities. In spite of natural recovery, the majority of these patients have residual muscle weakness and need nerve and/or secondary surgery to improve the utility of their arm. Long-term denervation results in muscle atrophy, fatty degeneration and interstitial fibrosis of the muscle. Quantitative tools which assess muscular fat content could improve insight in the extent of muscle degeneration and could facilitate a better treatment strategy.
Study objective
The purpose of this study is:
1. To develop a method to quantify muscular fat content in brachial plexus injury patients;
2. To investigate whether muscular fat content is more in the affected arm compared to the contra lateral arm in BPI patients;
3. To evaluate differences in muscular fat content between patient groups with insufficient recovery and with sufficient recovery of muscle function.
Study design
One timepoint at which MRI, physical examination and questionnaires will be performed.
Intervention
3 Tesla MRI of both upper arms.
Inclusion criteria
1. Brachial plexus injury patients with insufficient recovery of the musculus biceps brachii (MRC 0-3) will be included in group 1 and with a sufficient recovery (MRC 4) will be included in group 2;
2. Minimum 2 years after trauma or nerve surgery;
3. More then 18 years old.
Exclusion criteria
1. Bilateral brachial plexus injury;
2. Not 3 tesla MRI eligible due to any reason;
3. Not eligible to give informed consent.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2416 |
| NTR-old | NTR2524 |
| Other | MEC LUMC / ZonMW : P10.063 / 95100105 ; |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |