No registrations found.
ID
Source
Brief title
Health condition
Malignant hyperthermia
hypoxia
hypoxic ventilatory response
hypoxic pulmonary vasoconstriction
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Systolic PAP;
2. HVR.
Secondary outcome
1. Systolic and diastolic cardiac functions;
2. Vital and ventilatory parameters.
Background summary
The ryanodine receptor plays a crucial role in the development of the so called hypoxic pulmonary vasoconstriction. Malignant hyperthermia patients have a mutated ryanodine receptor. In this study we want to investigate the influence of the ryanodine receptor on the human response to hypoxia.
Study objective
1. What are the normoxic ventilation parameters and systolic PAP in MH patients?
2. What is the influence of hypoxia on the systolic PAP on MH patients?
Study design
1 hour.
Intervention
One hypoxic period of 1 hour.
LUMC, P5-Q
Rob Lindeman
Leiden 2300 RC
The Netherlands
+31 (0)71 5262301
c.r.lindeman@lumc.nl
LUMC, P5-Q
Rob Lindeman
Leiden 2300 RC
The Netherlands
+31 (0)71 5262301
c.r.lindeman@lumc.nl
Inclusion criteria
Healthy Malignant Hyperthermia patients with a phenotypic high susceptibility and a proven causative mutation.
The major inclusion criteria are that the subject has echo evidence of tricuspid regurgitation during systole, which is not clinically relevant but in fact can be demonstrated in most normal individuals.
Exclusion criteria
1. Obesity (BMI > 30);
2. Presence of medical disease: heart-, lung-, liver-, kidney- and lung disease; diabetes;
3. Presence of psychiatric disease:
A. History of chronic alcohol or drug use;
B. Possibility of pregnancy;
C. Lactation.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2656 |
| NTR-old | NTR2784 |
| Other | METC LUMC / CCMO : P11.013 / NL35083.058.11; |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |