No registrations found.
Source
Brief title
Health condition
COVID and DVT
Sponsors and support
Intervention
No registrations found.
Outcome measures
Primary outcome
Prevalence of VTE
Secondary outcome
Patient- and treatment characteristics associated with increased DVT risk
Background summary
Background: COVID-19 is associated with coagulopathy and disseminated intravascular coagulation. Furthermore, these patients are immobilized by illness and due to mandatory isolation. Frequently, this immobilization occurs already at home. The above makes patients prone to develop venous thromboembolism.
To prevent the development of venous thromboembolism during hospital admission, the majority of patients receives thromboprophylaxis. Nevertheless, the clinical impression has arisen that patients deteriorate acutely with symptoms compatible with acute lung embolism while using thromboprophylaxis. This might be explained by embolization of clots originating from asymptomatic deep vein thrombosis (DVT). Knowing whether patients have asymptomatic DVT is clinically relevant because treatment with a therapeutic dose of anticoagulants prevents embolization and improves survival. We don’t know whether we should perform ultrasound routinely in patients with COVID, as there is no literature on DVT prevalence yet.
Objectives: We aim to determine the prevalence of asymptomatic DVT in COVID patients admitted to the general ward.
Study design: This is a multicenter cross-sectional diagnostic study that will be performed in UMCG, UMCA location VUMC, Radboud, MUMC and possibly more collaborating centers.
Patients: aged ≥ 18 years admitted to the COVID ward without clinical suspicion of DVT, who provided informed consent.
Treatment of subjects: Ultrasound of both legs is performed once during hospital admission to determine whether patients have an asymptomatic proximal DVT (popliteal or femoral vein). If an asymptomatic DVT is diagnosed this will be treated according to the international guidelines with therapeutic dosed anticoagulants.
Patient data will be anonymously stored in a database.
Study objective
COVID patients have a higher prevalence of DVT than patients with other infectious diseases
Study design
cross-sectional diagnostic study
Intervention
None
Inclusion criteria
- Age (≥ 18 years)
- Proven (PCR) or suspected (based on clinical signs and imaging) COVID-19 infection
- Certified sonographer present
Exclusion criteria
- Clinical suspicion of DVT
- No informed consent obtained
- Absence of COVID infection
Design
Recruitment
IPD sharing statement
Plan description
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL8572 |
Other | METC UMCG : METc2020/199 |