No registrations found.
ID
Source
Brief title
Health condition
kidney transplantation
MRI
chronic renal allograft dysfucntion
niertransplantatie
chronisch nierfalen van transplantaatnieren
Sponsors and support
Intervention
Outcome measures
Primary outcome
Correlation of MR markers with interstitial fibrosis / tubular atrophy lesions on biopsy
Secondary outcome
Clinical markers of renal function
Differences in MR markers between groups
Background summary
The aim of the study is to detect (focal) interstitial fibrosis or rubular atrophy lesions in kidney allografts using MRI. Three groups of subjects are included: subjects >3 months after transplantation with stable graft function who preferably do have a routine kidney biopsy; subjects >6 months after transplantation suspect for chronic allograft dysfunction with an indication biopsy; healthy volunteers without kidney disease as comparison. All participants get a one-hour MRI scan to measure several functional parameters of kidney function. Correlations with biopsy and differences between groups will be investigated.
Study objective
To investigate whether it is possible to indicate (focal) interstitial fibrosis / tubular atrophy lesions in kidney allografts with MRI and compare these findings to the extent of interstitial fibrosis / tubular atrophy in the kidney biopsy that will be taken according to current clinical practice.
Study design
Single timepoint >3 months post transplantation
Intervention
-
Inclusion criteria
• Patients have undergone at least one kidney transplantation procedure.
• Patients are 18 year or older.
• Kidney biopsy is performed according to the existing guidelines for clinical practice just prior to or shortly after the MRI-scan has been performed
• Time between NTx and inclusion must be at least 3 months for patients with well functioning transplants and 6 months for patients with suspected chronic allograft dysfunction
Also healthy volunteers are included as comparison.
Exclusion criteria
• Subjects with contra-indications for MRI (like a pacemaker, an internal prosthesis or claustrophobia).
• Refusal of subjects to be informed of chance findings possibly relevant to their health.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7412 |
| NTR-old | NTR7637 |
| CCMO | NL53885.041.15 |
| OMON | NL-OMON47430 |