No registrations found.
ID
Source
Brief title
Health condition
Elderly, Frailty, Carnitine, Mitochondrial dysfunction
Ouderen, Kwetsbaarheid, Carnitine, Mitochondriale dysfunctie
Sponsors and support
Dr. Feike van der Leij
Food & Dairy Applied Research Centre
PO Box 1528, 8901 BV Leeuwarden
E-mail: feike.vanderleij@hvhl.nl
Food & Dairy Applied Research Centre
PO Box 1528, 8901 BV Leeuwarden
E-mail: feike.vanderleij@hvhl.nl
Medisch Centrum Leeuwarden
PO Box 888, 8901 BR Leeuwarden
Henri Dunantweg 2, 8934 AD Leeuwarden
Wageningen University
Human and Animal Physiology
PO Box 338, 6700 AH Wageningen
Rijksuniversiteit Groningen/Campus Fryslân
PO Box 7560, 8903 JN Leeuwarden
E-mail: campusfryslan@rug.nl
Sigma Tau BV
PO Box 2079, 3500 GB Utrecht
Intervention
Outcome measures
Primary outcome
Intramuscular carnitine levels and carnitine derivatives
Secondary outcome
Carnitine status and its derivatives in
PBMCs
Mitochondrial function in muscle tissue
and PBMCs
Fat and fat-free mass
Plasma carnitine and its derivatives
Short Physical Performance Battery
(SPPB)
400m walk time
Cognitive function
Background summary
Ageing is associated with increasing physical disabilities and prevalence of frailty, which negatively affects quality of life. In addition, ageing is also associated with a decrease in intramuscular carnitine levels. Simultaneously, intramuscular mitochondrial content and function decline. There are three studies describing the decline in intramuscular carnitine levels during ageing, but none of these studies did measure if
frailty status is associated with the degree of decline in carnitine status and mitochondrial function. In this study we are going to test the hypothesize that declined intramuscular carnitine levels are associated to declined mitochondrial function and, subsequently, to the frailty score.
Therefore the main objective is to compare the intramuscular carnitine status of prefrail/
frail elderly with fit elderly and young individuals. The secondary objectives are; 1)
determine if intramuscular carnitine status is associated with carnitine levels in PBMCs;
2) compare lean mass, physical function, muscle function/strength, cognitive function
and mitochondrial function in skeletal muscle and PBMCs between fit and pre-frail/frail
elderly, by using the healthy young individuals as a reference group.
Study objective
We hypothesize that declined intramuscular carnitine levels are associated to declined
mitochondrial function and, subsequently, to the frailty score. We suspect that prefrail/
frail elderly will have the lowest intramuscular carnitine levels and mitochondrial
function compared to the fit elderly and healthy young individuals, whereas fit elderly will have higher intramuscular carnitine status and mitochondrial function compared to pre-frail/
frail elderly, but lower compared to healthy young individuals.
Study design
All parameters will be measured within two weeks.
Intervention
A blood sample and muscle biopsy. In addition, participants will perform several physical and cognitive tests and fill in questionnaires.
M. van der Hoek
Food & Dairy Applied Research Centre - Postbus 1528
Leeuwarden 8901 BV
The Netherlands
+31(0)58 28 46 218
marjanne.vanderhoek@wur.nl
M. van der Hoek
Food & Dairy Applied Research Centre - Postbus 1528
Leeuwarden 8901 BV
The Netherlands
+31(0)58 28 46 218
marjanne.vanderhoek@wur.nl
Inclusion criteria
Healthy young subjects
- 20-30 years of age
- BMI of 20-25 kg/m2
Healthy fit elderly
- 75 years or older
- Fried score = 0
Pre-frail/frail elderly
- 75 years or older
- Fried score of 1 or more
Exclusion criteria
- Contra-indication for DEXA-scan, e.g. metal splinters
- Contra-indication for muscle biopsy, e.g. use of anticoagulants.
- a significant medical or surgical event or hospitalization within the previous three
months
- currently or the last three months treated by a medical specialist
- diagnosed with cardiac failure, COPD or anaemia
- diagnosed dementia and not having access to a daily caregiver and not able to make their own trade-off, which will be assessed at our discretion. The potential subjects have to be able to reproduce what is said;
- diagnosed with cancer or receiving cancer treatment
- not able to understand the Dutch language
- Diagnosed neuromuscular disorders
- taking carnitine supplements
- current participation in other research
- usage of the following medications:
o Systemic corticosteroids
o Fibrates
o Valproic acid
o Emetine
o Zidovudine
Additional exclusion criteria for the young individuals:
- Pregnant and nursing women
- Diabetes Mellitus type I and II
- Limited amount of performing sports, not more than 5 times a week
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5943 |
| NTR-old | NTR6124 |
| CCMO | NL58289.081.16 |
| OMON | NL-OMON43161 |