No registrations found.
ID
Source
Brief title
Health condition
Pancreatic cancer
Sponsors and support
Intervention
Outcome measures
Primary outcome
Correlation between preoperative imaging and IOUS regarding the assessment of resectability.
Secondary outcome
Change in surgical plan before and after IOUS, correlation between IOUS and pathological examination, resection margin status
Background summary
Determination of tumor extension and resectability of pancreatic cancer, especially after neoadjuvant chemotherapy, is troublesome on preoperative imaging. The assessment of vascular involvement is particularly important since these are the most affected resection margins, in addition a vascular resection can be performed to aim for a radical resection. The value of intra-operative ultrasound (IOUS) in adequate assessment of tumor extension, vascular involvement and resectability with subsequent IOUS-guided resection has scarcely been studied. This study aims to assess the added value and diagnostic accuracy of IOUS in predicting resectability of pancreatic cancer.
Study objective
Intra-operative ultrasound will change the resectability status in 15% of patients compared with pre-operative CT-scans.
Study design
The study is open for inclusion since November 2018. Expected study duration is 2 years.
Intervention
Intra-operative ultrasound
Inclusion criteria
Patients with pancreatic cancer planned for curative-intended resection, any vascular contact on pre-operative CT-imaging, treated with or without neoadjuvant chemotherapy, aged 18 years or older.
Exclusion criteria
Peri-ampullary cancer of non-pancreatic origin (i.e. duodenal carcinoma, papillary carcinoma, neuro-endocrine tumors or intra-papillary mucinous neoplasms without malignant degeneration)*. Pancreatic cancer in the absence of vascular involvement on (pre-treatment) computed tomography. *When in doubt between cancer malignancy or benign condition, inclusion/registration is allowed based on the rationale that curative-intent resection is also the treatment goal in these patients.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7621 |
| Other | METC LUMC : B18.018 |