No registrations found.
ID
Source
Brief title
Health condition
metabolic syndrome, diabetes mellitus
Sponsors and support
Intervention
Outcome measures
Primary outcome
changes in postprandial translocation of intestinal bacteria between donor and own ecal transplantation.
Secondary outcome
changes in (small) intestinal bacterial composition related to bacterial translocation.
changes in visceral and subcutaneous adipose tissue and inflammatory tone between donor and own fecal transplantation
Background summary
A relation exists between gutmicrobiota composition, plasma bacterial composition as well as adpose tissue bacterial signatures. We will thus study whether changes in gutmicrobiota composition using fecal transplantation affects bacterial signature in periferpheral tissue (blood/adipose tissue)
Study objective
we hypothesize that translocation of Gram- negative intestinal bacteria is associated with changes in (small) intestinal microbiota composition and can be influenced by fecal microbiota transplantation.
Study design
0 and 3/4 weeks
Intervention
fecal transplantation
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
Inclusion criteria
• Male sex
• Caucasian
• BMI >25 kg/m2
• At least 3 out of 5 NCEP metabolic syndrome criteria: fasting plasma glucose ≥5.6
mmol/l, triglycerides ≥1.7 mmol/l, waist-circumference >102 cm, HDL-cholesterol 1.04
mmol/l, blood pressure ≥130/85 mmHg
• Scheduled for laparoscopic cholecystectomy or laparascopic gastric bypass
• able to give informed consent
Exclusion criteria
• A history of cardiovascular event (CVA, MI or pacemaker implantation)
• Use of any medication including PPI and antibiotics in the past three months
• (Expected) prolonged compromised immunity (due to recent cytotoxic chemotherapy
or HIV infection with a CD4 count < 240/mm3)
• Presence of overt T2D
• Smoking
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4894 |
| NTR-old | NTR5141 |
| Other | METC : 2015_014 |