No registrations found.
ID
Source
Brief title
Health condition
Hand osteoarthritis (OA), rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients.
Sponsors and support
Intervention
Outcome measures
Primary outcome
The percentage of study joints in which a successful aspiration is performed.
Secondary outcome
The volume of the obtained synovia) fluid collections (~I);
• To analyse the presence of cytokines (such as IL-1, IL-6, IL-8, TNF-a), of immune cells (neutrophils, macrophages, lymphocytes) and adipokines and lipid mediators in the synovia) fluid;
• The relation between the US effusion score and volume of synovia) fluid that is aspirated from the study joint.
Background summary
Hand osteoarthritis (OA) is a prevalent disease of which the aetiology is largely unknown. Synovitis can frequently be found in hand joints of OA patients with the use of imaging modalities such as ultrasonography (US). Although synovitis is thought to be involved in clinical features and development of structural damage, its exact role is currently not elucidated. Therefore, the investigation of synovia/ tissue would be of great interest.
However, synovia/ tissue can only be obtained via an invasive procedure, which is not easy
in small hand joints. Alternatively, it might be possible to obtain synovia/ fluid, which is a
reflection of the processes going on in the synovia/ tissue, and is therefore also of interest to study.
Study objective
To investigate the feasibility of aspiration of synovia/ fluid from inflamed small OA hand joints
and in case synovia/ fluid can be obtained, to investigate which analyses can be performed
on the amount of fluid obtained.
Study design
single study visit
Intervention
not applicable
Inclusion criteria
1. Diagnoses of hand OA, rheumatoid arthritis, or psoriatic arthritis according to recognised classification criteria sets;
2. Presence of an inflamed interphalangeal or MCP joint for which the treating rheumatologist has proposed treatment with an intra-articular injection with corticosteroids;
3. Patients should be 40 years of age or older.
Exclusion criteria
1. Patients that had an intra-articular injection with corticosteroids, an operation or an important trauma in the same joint less than 12 weeks before the intended injection;
2. The presence of a chronic inflammatory disease (other than OA, rheumatoid
arthritis or psoriatic arthritis), such as poly-articular gout;
3. Contra-indication for an intra-articular injection such as anti-coagulant (vitamin K
antagonist) use that can't be discontinued.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7283 |
| NTR-old | NTR7517 |
| CCMO | NL61359.058.17 |
| OMON | NL-OMON53105 |