No registrations found.
ID
Source
Brief title
Health condition
Preterm birth (prematuriteit)
Asthma (astma)
Lung function (longfunctie)
Exercise capacity (inspanningscapaciteit)
Lung Clearance Index (LCI)
Sponsors and support
Intervention
Outcome measures
Primary outcome
Spirometrie : FVC, FEV1, FEV1/FVC, FEF25, FEF50, FEF75, PEF
Ergometire : Hartfrequentie, ademhalingsfrequentie, maximalebelasting, VO2rust, maximale ademfrequentie, VT, VTmax, VEmax, ventilatoire reserve, VO2 op de anaerobe drempel (AD), VO2max, AD, AD/VO2, ΔVO2/ΔWR, respiratory exchange ratio, Borg score
LCI : LCI, Scon, Salv
Secondary outcome
no
Background summary
There has been much research into lung problems in extremely preterm children. A "forgotten group" is the group of children born between 32 and 36 weeks gestation. Research shows that at age 5, these children do indeed have respiratory symptoms, and report a doctor's diagnosis of asthma more often. This study is to determine how these children are at the age of 12 in the respiratory field. To investigate this, we use questionnaires, LCI, spirometry and exercise testing.
Study objective
The hypothesis is that modarate and late preterm infants at age 12 reported more symptoms consistent with asthma and use more asthma medications, as well as a poorer lung function, exercise capacity and Lung Clearance Index than healthy peers.
Study design
March 2014: authorization procedure Metc
September 2014: Sending information letters to parents
September 2015- January 2015: Planning and performing measurements
January 2015: analyze data
Intervention
Questionnaires (general, ISAAC, PAQ C)
Ergometrie
Spirometrie
Lung Clearance Index
UMCG/Beatrix Children’s Hospital CA 43 <br>
Department of Pediatric Pulmonology and Pediatric Allergologie <br>
PO BOX 30.001
E.J.L.E. Vrijlandt
Groningen 9700 RB
The Netherlands
+31 50 3612475
e.j.l.e.vrijlandt@umcg.nl
UMCG/Beatrix Children’s Hospital CA 43 <br>
Department of Pediatric Pulmonology and Pediatric Allergologie <br>
PO BOX 30.001
E.J.L.E. Vrijlandt
Groningen 9700 RB
The Netherlands
+31 50 3612475
e.j.l.e.vrijlandt@umcg.nl
Inclusion criteria
Research group
- Born between 32 and 36 +6 weeks of gestation
- From one of the three northern provinces (Drenthe, Groningen and Friesland)
Control group
- Born after 37 weeks gestation
- From one of the three northern provinces (Drenthe, Groningen and Friesland)
Exclusion criteria
Research group
- Duration of pregnancy precisely determined by ultrasound
- Physical inability to carry out fietsergometrietest
- Birth Defects
- Illness or fever at the time of measurement
Control group:
- Duration of pregnancy is not exactly determined by ultrasound
- Physical inability to carry out fietsergometrietest
- Birth Defects
- Use of bronchodilators
- Illness or fever at the time of measurement
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4444 |
| NTR-old | NTR4567 |
| Other | : not yet available |