No registrations found.
ID
Source
Brief title
Health condition
Endometriosis, Retrograde menstruation, theory of Sampson.
Sponsors and support
Intervention
Outcome measures
Primary outcome
The difference in the amount of blood-stained peritoneal fluid measured by TVUS and MRI in women with endometriosis versus healthy controls.
Secondary outcome
1. The localisation and amount of resorption of blood stained peritoneal fluid;
2. The volume and aspect of endometrial cysts;
3. Signal intesity and thickness of the junctional zone in endometriosis patients and controls;
4. Apperent Diffusion coefficient (ADC) in endometrial cysts, myometrium and junctional zone.
Background summary
Endometriosis is defined as the presence of endometrial- like tissue (which is in normal circumstances only inside the uterus) within the pelvis and other extra-uterine sites. It is a common estrogen dependant disease which is thought to affect up to 10% of women of reproductive age. This can rise up to 35-50% in women presenting with pelvic pain and infertility or both. The etiology remains unclear. Sampson described the theory of menstruation in 1927. This theory describes the backflow of menstrual fluid from the uterine cavity through the tubes to the peritoneal cavity. In this study we will test this theory with modern imaging techniques (TVUS and MRI).
Study objective
To validate the hypothesis by Sampson on retrograde menstruation by using modern imaging modalities.
Study design
N/A
Intervention
On Cycleday 2 and Cycleday 20 a gynaecological investigation, a transvaginal ultrasound and MRI will be performed. Also a bloodsample (serum Ca 125) will be collected.
In case of a cystectomy also a pippelle from the endometrium will be taken.
A.B. Luchinger
Amsterdam 1081 HV
The Netherlands
+31 (0)20 4445278
abluchinger@vumc.nl
A.B. Luchinger
Amsterdam 1081 HV
The Netherlands
+31 (0)20 4445278
abluchinger@vumc.nl
Inclusion criteria
1. Female<40 years;
2. Subfertility;
3. Patent tubes (at HSG or laparoscopy with chromopertubation);
4. Regular menstrual cycle (28 days +/- 3 days);
5. Cases: presence of endometriosis confirmed by laparoscopy;
6. Controls: no presence of endometriosis confirmed by laparoscopy;
7. Signed informed consent;
8. Negative pregnancy test.
Exclusion criteria
1. Female age>40 years;
2. Hormone therapy;
3. Contra indications for MR imaging (e.g.pacemaker, claustrophobia);
4. Positive pregnancy test;
5. Laparoscopy > 1 year ago;
6. Evidence of tubal occlusion seen at HSG or laparoscopy;
7. Presence of any malignancy;
8. Frozen pelvis.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2106 |
| NTR-old | NTR2223 |
| Other | METc VUmc : 2009/329 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |