No registrations found.
ID
Source
Brief title
Health condition
Spinal cord injury
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Identification of the autoantibodies produced after SCI.
- Characterisation of the autoantibody response after SCI in patients over time.
- Assessment of the association between clinical outcome parameters and changes in antibody levels: determining the prognostic biomarker potential of the candidate biomarkers.
Secondary outcome
- Determine immune cell subtypes and function, immune derivatives, inflammatory and neurological markers in peripheral blood at multiple time points following spinal cord injury.
- Assessment of the association between the clinical outcome parameters and the changes in immunological and neurological parameters in SCI patients.
Background summary
This project focuses on the characterization of the immune response following a traumatic SCI. As individual components of the immune response work in close collaboration and have a strong influence on each other, it is important to obtain a very detailed and elaborate overview of the immune response. Therefore we will examine different aspects of the immune response in this project. Hereby, autoantibodies, immune cell populations, immune components, inflammatory and neurodegeneration markers will be investigated.
Study objective
The peripheral immune response is changed following a traumatic spinal cord injury.
Study design
1. Admission in the rehabilitation center
2. 3 weeks after spinal cord injury (SCI)
3. 6 weeks after SCI
4. 12 weeks after SCI
5. 6 months after SCI
6. 1 year after SCI
Inclusion criteria
- Individuals older than 18 years
- Diagnosis of spinal cord injury.
Exclusion criteria
- Individuals with pre-existing autoimmune diseases
- Use of anti-inflammatory or immune modulatory treatment.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8803 |
| Other | METC azM/UM : not known yet |