No registrations found.
ID
Source
Brief title
Health condition
high blood pressure, overweight, dietary proteins and carbohydrates
hoge bloeddruk, overgewicht, voedingseiwitten en -koolhydraten
Sponsors and support
Maastricht University
Maastricht
The Netherlands
Wageningen
The Netherlands
Intervention
Outcome measures
Primary outcome
Change in office and 24-h ambulatory blood pressure after 4 weeks intervention
Secondary outcome
Acute postprandial effects on cardiac output, renal blood flow, forearm blood flow, endothelial function, sympathetic nervous system activity, renal function, ACE activity
Change in acute postprandial effects on cardiac output, renal blood flow, forearm blood flow, endothelial function, sympathetic nervous system activity, renal function, ACE activity after 4 weeks intervention
Background summary
This trial will investigate the blood pressure lowering effect of dietary proteins and explore its underlying mechanism of action.
Study objective
Lowering of daily carbohydrate intake by 10% of total energy intake and isocaloric replacement by protein intake during 4 weeks will significantly reduce office and ambulatory blood pressure in overweight subjects with prehypertension or grade 1 hypertension.
Study design
Baseline, 4 weeks intervention
Intervention
Carbohydrate (maltodextrine) supplementation vs protein (mixture of dietary proteins) supplementation, 10% of total energy intake, isocaloric
Department of Human Biology
P.O. Box 616
M.A. Baak, van
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881630
m.vanbaak@hb.unimaas.nl
Department of Human Biology
P.O. Box 616
M.A. Baak, van
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881630
m.vanbaak@hb.unimaas.nl
Inclusion criteria
1. Men and women
2. BMI 25-30 kg/m2
3. High normal or untreated grade 1 hypertension (systolic blood pressure 130-159 mmHg, diastolic blood pressure 85-99 mmHg)
4. Age 20-65 years
Exclusion criteria
1. Smokers
2. Food allergies
3. Unwillingness to stop use of dietary supplements (except those provided in the study)
4. Use of prescription medication
5. Recent history of or current dieting
6. Gastrointestinal problems
7. Plasma creatinine < 60 mmol/L
8. Presence of urinary protein (stick test)
9. Fasting glucose > 7 mmol/L
10. At randomisation: average blood pressure of visits 1 and 2 outside inclusion range for blood pressure
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1313 |
| NTR-old | NTR1362 |
| Other | MEC : 08-3-041 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |