No registrations found.
ID
Source
Brief title
Health condition
Vitamin D, UVB irradiation, dementia, well-being, nursing home, long-term care
Sponsors and support
• VDL Hapro, Kapelle
Intervention
Outcome measures
Primary outcome
Well-being, monitored with the CMAI (Cohen-Mansfield Agitation Inventory) and the Cornell scale for depression in dementia at 0, 3 and 6 months.
Secondary outcome
• Vitamin D status
• Calcium homeostasis
Background summary
Background: in older people, vitamin D supplementation by UVB irradiation may be preferable to oral supplementation: it cannot cause toxic levels; it is cheap and easy to apply and it helps in preventing polypharmacy. Moreover, there are indications that UVB exposure has additional beneficial effects on health and well-being by other mechanisms than the vitamin D-pathway alone. UVB irradiation has shown to be effective in increasing 25(OH)D serum levels in nursing home residents.
Objective: comparing the additional effects of UVB irradiation to oral vitamin D-supplementation on well-being in psycho-geriatric nursing home residents.
Method: A randomized controlled trial. Subjects are psycho-geriatric nursing home residents (N=80) admitted in two Dutch nursing homes. The intervention consists of half-body UVB irradiation, two times a week, over 6 months, with 0.5 minimal erythemal dose (MED), compared to oral supplementation with 5600 IE cholecalciferol once a week. Main outcome measure is Well-being, monitored by asking the nursing staff to complete the CMAI (Cohen-Mansfield Agitation Inventory) and the Cornell scale for depression in dementia at 0, 3 and 6 months.
Study objective
UVB irradiation has an additional effect on well-being compared to oral vitamin D-supplementation in psycho-geriatric nursing home residents.
Study design
baseline (0 months), 3 and 6 months
Intervention
The intervention consists of half-body UVB irradiation, two times a week, over 6 months, with 0.5 minimal erythemal dose (MED), compared to oral supplementation with 5600 IE cholecalciferol once a week.
Dept. Public Health and Primary Care
B. Veleva
Postbus 9600
Leiden 2300 RC
The Netherlands
+31 (0)71 526 8444
B.I.Todorova-Veleva@lumc.nl
Dept. Public Health and Primary Care
B. Veleva
Postbus 9600
Leiden 2300 RC
The Netherlands
+31 (0)71 526 8444
B.I.Todorova-Veleva@lumc.nl
Inclusion criteria
• > 70 years of age
Exclusion criteria
• contraindications against ultraviolet radiation: actinic damaged skin including, skin cancer, sun allergy, porphyrias, use of drugs that can induce photodermatoses.
• contraindications to treatment with vitamin D3 such as hypercalcemia and sarcoidosis
• the use of vitamin D fortified supplementary feeding
• in the context of the underlying dementia, frequent anxiety or fear or aggression and known resistance to physical contact (e.g. blood tests)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5704 |
| NTR-old | NTR5857 |
| Other | : P16.010 |