Kan warmte post-prandiale endotheel dysfunctie voorkomen?

Rationale:

Endothelial dysfunction contributes to the development of vascular complications in type 2 Diabetes Mellitus (T2DM). Elevation in glucose level (i.e. hyperglycaemia) is demonstrated to contribute to a transient decrease in endothelial function, especially in T2DM as these subjects demonstrate prolonged hyperglycaemia after a glucose load compared to healthy controls.


In previous studies, we have demonstrated that elevation in blood flow can improve endothelial function in healthy subjects. Accordingly, elevation in blood flow may also counteract the impact of hyperglycaemia on endothelial function in T2DM and their age-matched controls.

Objectives:

To examine whether heating can prevent the hyperglycaemia-induced decline in endothelial function in T2DM and age -matched controls.

Study design:

Cross-sectional observational study

Study population:

10 subjects with T2DM and 10 age -matched controls

Intervention (if applicable):

Not applicable

Main study parameters/endpoints:

The change in endothelial function after 75-gr glucose (measured as the brachial artery flow-mediated dilation at 3 distinct time-points).


Nature and extent of the burden and risks associated with participation, benefit and group relatedness:

We will take a total of four venous blood samples from each subject. Taking a blood sample is associated with a 5% risk of developing a haemorrhage, which is not associated with any functional limitations and will disappear within 2 weeks. To minimise the potential risk, a venous ‘line’ is introduced once which facilitates repeated venous blood withdrawals. Other measures/interventions (75 gr glucose load, heating, echo-Doppler, 5-minutes cuff inflation) are not associated with any potential health risk.

Warmte zorgt voor toename van de doorbloeding, welke lokaal een afname van de endotheelfunctie na een maaltijd kan voorkomen.

Before and after (1, 2 and 2.5 h) 75-gr glucose

Local heating