No registrations found.
ID
Source
Brief title
Health condition
- Albinism accompanied by IN
- Idiopathic IN
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Near and distance visual acuity
- Crowding intensity
Secondary outcome
- Contrast sensitivity function
- Stereopsis
- Reading performance
- Eye movements (fixation stability and saccade execution)
- Compliance
- Training joy
- Vision related quality of life
Background summary
Our previous project has demonstrated that a computerized visual perceptual learning paradigm can improve visual performance in children with infantile nystagmus (IN). Nevertheless, there are still some problems preventing implementation: 1) the current version of the training is not suitable as a home-based app and only runs in MATLAB, 2) it is unclear how much training is needed before subjects reach optimal performance, and 3) the available vision charts to measure crowded acuity are too loosely spaced. The goal of the current project is to deliver a clinical training tool to induce substantial, long-term vision improvements in children with IN and develop a crowding app.
This project concerns: 1) an intervention study (one-arm, one group pretestposttest design), and 2) a validation study (prospective cohort study). For the intervention project, we aim to include 40 children (age 8-18-years) with the diagnosis albinism accompanied by infantile nystagmus or idiopathic infantile nystagmus. Thirty 8-18 year old children with normal vision will be included to determine testretest variability and interest agreement of the new crowding app.
Study objective
- Extensive perceptual learning (40 sessions) results in larger training gains than short perceptual learning (10 sessions).
- Children with idiopathic infantile nystagmus (IN) show larger training gains than children with albinism accompanied by IN.
Study design
T0 = pretest measurements right before training
T1 = posttest measurements directly after training
T2 = follow up measurements 6 months after training
Intervention
Computerized visual perceptual learning
Donders Institute for Brain, Cognition and Behaviour Radboudumc
B. Huurneman
Geert Grooteplein 21
Nijmegen 6525 EZ
The Netherlands
T: +31 243 613 326
E: B.Huurneman@donders.ru.nl
Donders Institute for Brain, Cognition and Behaviour Radboudumc
B. Huurneman
Geert Grooteplein 21
Nijmegen 6525 EZ
The Netherlands
T: +31 243 613 326
E: B.Huurneman@donders.ru.nl
Inclusion criteria
Children with IN:
- Age 7-18 years (n = 40)
- Diagnosis albinism (with IN) or idiopathic IN
- Binocular visual acuity ≥20/400 and < 20/20.
- No additional (neurological or motor) impairments
- Born at term with normal birth weight (≥3000 gr)
Children with normal vision:
- Age 8-18 years (n = 30)
- Binocular visual acuity ≥20/20
- Born at term with normal birth weight (>3000 gr)
Exclusion criteria
Children with IN:
- Received computerized visual perceptual learning before
- Neurological conditions such as cerebral visual impairment, oculomotor apraxia, hemianopia, developmental disorders.
- Visual acuity <20/400 or ≥ 20/20.
Children with normal vision:
- Motor or mental impairments
- The presence of a developmental disorder
- Binocular visual acuity <20/20
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6711 |
| NTR-old | NTR6881 |
| CCMO | NL61860.091.17 |
| OMON | NL-OMON47749 |
Summary results
• Huurneman, B., Boonstra, F.N., & Goossens, J. (2016). Perceptual learning in children with infantile nystagmus: effects on visual performance. Investigative Ophthalmology & Visual Science, 57(10), 4216-4228. <br>
• Huurneman, B., Boonstra, F.N., & Goossens, J. (2016). Perceptual learning in children with infantile nystagmus: effects on 2D oculomotor behavior. Investigative Ophthalmology & Visual Science, 57(10), 4229-4238. <br>
• Huurneman, B., Boonstra, F.N., & Goossens, J. (2016). Perceptual learning in children with infantile nystagmus: effects on reading performance. Investigative Ophthalmology & Visual Science, 57(10), 4239-4246.