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ID
Source
Brief title
Health condition
Sarcopenia
Sponsors and support
Intervention
Outcome measures
Primary outcome
Muscle protein synthesis
Secondary outcome
Satiety; plasma glucose; insulin; plasma lipid profile; blood pressure
Background summary
A major cause of global environmental change is food production, with animal based food products having the greatest impact on the environment. Therefore, consumers are increasingly encouraged to consume more plant-based foods and lower their consumption of foods from animal origin. However, the consequences of such a transition on muscle mass still remains to be explored. This is of particular importance in the older population, where sarcopenia is highly prevalent. Therefore, we aim to investigate the short-term effect of a vegan diet on daily muscle fractional synthesis rates in comparison to an omnivorous diet in community-dwelling older adults. The study will have a randomized controlled cross-over design and will include healthy older adults, aged 65-79 years.
Study objective
The vegan diet will differently affect muscle protein synthesis rates in older adults than the omnivorous diet.
Study design
Baseline; 10 days; 20 days
Intervention
Vegan diet
Inclusion criteria
Aged 65-79 years old; Community-dwelling; BMI 20-35 kg/m2.
Exclusion criteria
- Following a vegetarian or vegan diet during the six months prior to the study;
- Following a diet that affects protein intake during the six months prior to the study;
- Participating in a structured exercise training program in the past three months;
- ≥5% of body weight loss during three months before the start of the study;
- Being diagnosed with one of the following: diabetes; renal disease; neurological or neuromuscular disorders; serious cardiovascular diseases; cancer; chronic obstructive lung disease (COPD);
- Chronic use of medication that affects muscle function, e.g. corticosteroids, metformin, insulin;
- The use of the following medicines: acenocoumarol (sintrom); phenprocoumon (marcoumar); dabigatran (pradaxa); apixaban (eliquis); rivaroxaban (xarelto); clopidogrel (plavix); combination of acetylsalicylic acid or carbasalate calcium (ascal) with dipyridamole.
- Allergic or intolerant to any product included in the diets;
- Not willing to stop nutritional supplements, with the exception of supplements on medical advice, and vitamin D;
- Not willing or afraid to give blood or undergo a muscle biopsy during the study;
- Unwilling to eat a vegan and an omnivorous diet for ten days each;
- Not vaccinated for COVID-’19;
- Currently a research participant in another trial or participated in a clinical trial during three months before the start of the measurement period;
- Not being able to understand Dutch;
- Not having a general physician.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9542 |
| CCMO | NL76916.028.21 |
| OMON | NL-OMON51234 |