No registrations found.
ID
Source
Brief title
Health condition
Depth of Anaesthesia
Auditory Evoked Potentials
Paediatric Anaesthesia
BIS monitor
aepEX
Sponsors and support
Dep. of Anaesthesia
Paediatric Anaesthesia Unit - Sophia Children's Hospital
Erasmus University Medical Center, Rotterdam
Dep. of Anaesthesia
Intervention
Outcome measures
Primary outcome
The performance of the aepEX™ as a measure of DoH in paediatric patients (1-18 years old), anaesthetised with propofol, sevoflurane or desflurane. The accuracy of the aepEX™ will be expressed in Pk-values.
Secondary outcome
The effects of different propofol concentrations, (applied by Target Controlled Infusion), sevoflurane and desflurane concentrations on the aepEX, the University of Michigan Sedation Scale (UMSS), BIS and hemodynamic variables.
MLAEP latencies and amplitudes will be extracted from the raw-MLAEP waveforms and linked to propofol plasma, sevoflurane and desflurane concentrations and the UMSS.
Background summary
N/A
Study objective
N/A
Study design
During anaesthesia, including induction and emergence.
Intervention
N/A
Y.M. Cheung
Erasmus MC - Sophia
Kamer SH 3603
Rotterdam 3000 CB
The Netherlands
y.m.cheung@erasmusmc.nl
Y.M. Cheung
Erasmus MC - Sophia
Kamer SH 3603
Rotterdam 3000 CB
The Netherlands
y.m.cheung@erasmusmc.nl
Inclusion criteria
1. Age 1-18 years;
2. General anaesthesia;
3. Planned elective surgery.
Exclusion criteria
1. Significant hearing impairment;
2. Intake of drugs affecting the EEG;
3. Having a disorder affecting the EEG;
4. Allergy for propofol, remifentanil, sevoflurane and/or desflurane;
5. Planned PICU admission post-operatively with ventilatory support and sedation;
6. Unable to obtain written informed consent.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2841 |
| NTR-old | NTR2983 |
| Other | MEC Erasmus MC : 2011-104 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
Summary results
<br><br>
Cheung YM, Scoones GP, Stolker RJ, Weber F. Evaluation of the auditory evoked potentials derived aepEX() as a measure of hypnotic depth in pediatric patients receiving sevoflurane-remifentanil anesthesia. Paediatric anaesthesia. 2014;24(7):760-5.