No registrations found.
ID
Source
Brief title
Health condition
hyperplastic polyposis CRC serrated adenoma HPSB colorectal carcinoma HPS
Sponsors and support
Intervention
Outcome measures
Primary outcome
To prospectively assess the efficacy, feasibility and safety of a systemised endoscopic surveillance protocol in large multicentre HPS cohort.
Secondary outcome
The incidence of complications: The amount of polypectomies and the rate of protcol deviations and conversions to surgical resection will be assessed.
Background summary
Hyperplastic polyposis syndrome (HPS) is characterized by the presence of multiple colorectal serrated polyps and is associated with an increased colorectal cancer (CRC) risk. The prevalance of HPS is estimated to be 1:3000 which makes HPS more common than other polyposis syndromes such as FAP. Due to the risk of malignant polyp transformation, HPS patients undergo endscopic surveillance with removal of polyps or a surgical colonic resection. However, no uniform and adequately substantiated endoscopic management protcol exists regarding polyp removal and surveillance intervals.
Aim:
To prospectively assess the efficacy, feasibility and safety of a systemised endoscopic surveillance protocol in large multicentre HPS cohort.
Study objective
To prospectively assess the efficacy, feasibility and safety of a systemised endoscopic surveillance protocol in large multicentre HPS cohort.
Study design
3 years.
Intervention
Data are collected in prospective manner from patients during a routine annual endoscopies with removal of all polyps < 3 mm.
Y. Hazewinkel
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5662806
y.hazewinkel@amc.uva.nl
Y. Hazewinkel
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5662806
y.hazewinkel@amc.uva.nl
Inclusion criteria
HPS patients defined as:
> 5 HPs/SSA proximal to the sigmoid, of which 2 > 10 mm in diameter, or more than 20 HPs/SSAs distributed throughout the colon.
Exclusion criteria
Carriers of a germline mutation in the MutYH or APC gene and individuals who have undergone a total colonic resection.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2629 |
| NTR-old | NTR2757 |
| Other | METC AMC : 10.17.2005 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |