No registrations found.
ID
Source
Brief title
Health condition
ICU-acquired weakness, CIP, CIM, CINM, critical illness polyneuropathy, critical illness myopathy, criticall illness neuromyopathy
Sponsors and support
Department of Intensive Care and Department of Neurology
Department of Intensive Care and Department of Neurology
Intervention
Outcome measures
Primary outcome
Difference in gray-scale value as measures of echointensity on standardized cross-sectional ultrasonographic views of five muscle groups in patients with ICU-AW and patients without ICU-AW.
Secondary outcome
- Differences in standard deviation of the gray scale values as a measure of homogeneity of the five muscle groups between patients with ICU-AW and patients without ICU-AW.
- Differences in cross-sectional muscle thickness as measure of muscle atrophy of the five muscle groups between patients with ICU-AW and patients without ICU-AW.
- Differences in area and vascularity on standardized ultrasonographic views of median nerve and peroneal nerve.
Background summary
Intensive Care Unit-acquired weakness (ICU-AW), a frequently occurring complication of critical illness. Ultrasound examination of the neuromuscular system has been shown to improve diagnostic accuracy in various neuromuscular diseases. However, diagnostic accuracy of ultrasound examination for ICU-AW has not been investigated.
The aim of this study is to evaluate whether neuromuscular ultrasound discriminates between patients with and without ICU-AW.
In this prospective cross-sectional survey, adult patients admitted to the ICU of the Academic Medical Center, who require mechanical ventilation for at least two days, will be included. The presence of ICU-AW will be assessed by the attending physiotherapist, using the Medical Research Council score. Thereafter, an extensive neuromuscular ultrasound examination will be performed.
The main study endpoint is the difference in gray-scale value, as measures of echointensity, on standardized cross-sectional ultrasonographic views of five muscle groups in patients with ICU-AW and patients without ICU-AW.
Study objective
Neuromuscular ultrasound can discriminate between patients with and without ICU-AW
Study design
Single timepoint for neuromuscular ultrasound just after valid muscle strength assessment
Intervention
Muscle strength will be investigated by the attending physiotherapist, using the Medical Research Council (MRC) sumscore to assess the presence of ICU-AW.
Next, blinded to the strength evaluation, neuromuscular ultrasound examination will be performed.
Department of Neurology,
P.O. Box 22660
C. Verhamme
Meibergdreef 9
Amsterdam
The Netherlands
+31 (0)20 5663856
c.verhamme@amc.uva.nl
Department of Neurology,
P.O. Box 22660
C. Verhamme
Meibergdreef 9
Amsterdam
The Netherlands
+31 (0)20 5663856
c.verhamme@amc.uva.nl
Inclusion criteria
-Adult patients newly admitted to the ICU
-Mechanical ventilation for at least 48 hours
-Feasible evaluation of ICU-AW according to international standard with the MRC scale
Exclusion criteria
-Neuromuscular disorder as reason for admission
-Stroke (ischemic, hemorrhagic or subarachnoid) as reason for admission
-Quadriplegia due to spinal cord syndrome in medical history or as reason for admission
-Out of hospital cardiac arrest as reason for admission
-Traumatic brain injury as reason for admission
-Known intracerebral space occupying lesion
-Poor functional status before admission (modified Rankin score 4 or 5)
- >= 2 extremities available for testing
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3925 |
| NTR-old | NTR4148 |
| CCMO | NL41156.018.12 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON41662 |