No registrations found.
ID
Source
Brief title
Health condition
ALI, ARDS, eNOSE, sepsis, mechanical ventilation.
ALI, ARDS, eNOSE, sepsis, beademing.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Electronic nose smellprint.
Exhaled air is collected via a connector in the circuit of the mechanical ventilator near the tube and, if present, proximal to the filter. The connector is attached to the electronic nose (Cyranose 320) and measurements are taken for 60 seconds.
When exposed to a gas mixture, the sensors of the electronic nose will swell and thus change the electrical conductance, resulting in a unique smellprint.
Secondary outcome
- Lung injury score.
Background summary
Critically ill patients may develop acute lung injury (ALI) or its more severe form acute respiratory distress syndrome (ARDS), which can be the result of either a pulmonary insult (e.g., pneumonia) or indirect injury (e.g., sepsis). Early and adequate recognition of ALI/ARDS is mandatory for intensive care physicians to take sufficient actions at the right time. In today’s intensive care practice, ALI/ARDS is diagnosed and monitored by clinical symptoms, radiology findings and laboratory measurements.
However, diagnosing ALI/ARDS remains challenging. Exhaled breath molecular profiling using electronic nose technology can potentially be usefull in diagnosing as well as monitoring lung injury in mechanically ventilated patients.
Study objective
1. We postulate that an electronic nose can discriminate exhaled breath of patients with ALI/ARDS lung injury from patients without lung injury and without being at risk for developing lung injury
2. We postulate that an electronic nose can recognize worsening or improvement of lung injury in patients at risk for ALI/ARDS
3. We postulate that an electronic nose can predict the development of ALI/ARDS in patients at risk for ALI/ARDS
Study design
The electronic nose will measure the exhaled breath of the included patients once every day.
Intervention
No interventions, diagnostic study.
Academic Medical Center (AMC) <br>
University of Amsterdam<br>
Department of Pulmonology <br> F5-260 <br>
P.O.Box 22660
Niki Fens
Meibergdreef 9
1100 DD
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664359
N.Fens@amc.nl
Academic Medical Center (AMC) <br>
University of Amsterdam<br>
Department of Pulmonology <br> F5-260 <br>
P.O.Box 22660
Niki Fens
Meibergdreef 9
1100 DD
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664359
N.Fens@amc.nl
Inclusion criteria
1. Patients with established ALI/ARDS according to the American/European Consensus Criteria
2. Patients at risk for developing ALI/ARDS
3. Patients without lung injury, not at risk for developing ALI/ARDS and not known to a have pre-existent pulmonary condition
Exclusion criteria
1. Younger than 18 years of age
2. Pregnancy
3. Current malignancy
4. Use of steroids in higher than hysiologic dosages (300 mg hydrocortisone or equivalent)
5. Recent cardiopulmonary surgery (reason for admittance)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1488 |
| NTR-old | NTR1558 |
| Other | METC AMC : AMC20080915.1 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |