No registrations found.
ID
Source
Brief title
Health condition
Obesity
Insulin resistance
Type 2 diabetes mellitus
Sponsors and support
Intervention
Outcome measures
Primary outcome
Circulating and tissue levels of RBP4, in relation to:
1. Endogenous glucose production;
2. Hepatic, peripheral and adipose tissue insulin sensitivity;
3. Hepatic triglyceride content.
Secondary outcome
Correlation levels of RBP4 with hepatic enzymes involved in gluconeogenesis.
Background summary
Retinol binding protein (RBP4) is a small 21 kDa protein that belongs to the family of lipocalins. RBP4 is primarily synthesized in hepatocytes, but other sites of synthesis are known including adipocytes. Recently RBP4 has been proposed as an adipokine that is involved in obesity-induced insulin resistance. We aim to assess whether serum and tissue RBP4 levels are elevated in these metabolically altered states and whether these levels are correlated with glucose fluxes. This gives more insight in the pathophysiological role of RBP4 in glucose intolerance and diabetes in obesity and will shed light on whether it would be useful to develop agents that decrease RBP4 expression.
Study objective
Liver and adipose tissue levels as well as serum levels of RBP4 are higher in obese subjects compared to lean subjects. In obese subjects tissue and serum levels of RPB4 are correlated with insulin sensitivity and hepatic triglyceride content.
Study design
1. Screening;
2. Two weeks presurgery;
3. Surgery.
Intervention
N/A
Inclusion criteria
1. Female;
2. BMI > 35 kg/m2;
3. Age between 26 and 50 years;
4. Established T2DM.
Exclusion criteria
1. Primary lipid disorder or secondary lipid disorder treated with fibrates;
2. T2DM treated with thiazolidinediones, DPP4-inhibitors or GLP1-analogues;
3. Any medical condition except for glucose intolerance, hypertension and secondary dyslipidemia;
4. Bleeding disorder;
5. Untreated primary hypothyroidism;
6. Contra-indications for MR scanning.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3651 |
| NTR-old | NTR3835 |
| Other | METC AMC : 12/314 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |