No registrations found.
ID
Source
Brief title
Sponsors and support
PO box 2060
3000 CB ROTTERDAM
+31-10-4636079/4636750
fax: +31-10-4365548
info@vriendensophia.nl
PO box 2060
3000 CB ROTTERDAM
+31-10-4636079/4636750
fax: +31-10-4365548
info@vriendensophia.nl
Intervention
Outcome measures
Primary outcome
Glutathione synthesis rate.
Secondary outcome
1. Concentration of oxidative stress markers, Apgar Score, oxygen saturation and heart rate in first 20 minutes after birth;
2. Mortality;
3. The incidence of bronchopulmonary dysplasia.
Background summary
Preterm infants are subjected to increased formation of reactive oxygen species and have reduced antioxidant defenses. The resulting oxidative stress is thought to play an important role in mortality and incidence of neonatal diseases like bronchopulmonary dysplasia.
Birth is accompanied by sudden exposure to increased oxygen pressure, which results in increased formation of reactive oxygen species. In term infants, resuscitation at birth with 100% oxygen leads to increased oxidative stress and mortality. Thus, the current recommendations are to start resuscitation of all infants with 21% oxygen. However, it seems that 21% oxygen is not enough for preterm infants.
Therefore, we will determine safety, efficacy and oxidative stress of the use of different oxygen concentrations with preterm at birth.
Study objective
Resuscitation after birth with 30% oxygen reduces oxidative stress and is safe in preterm infants.
Study design
1. Glutathione synthesis: at day 2 postnatal;
2. Concentration of oxidative stress markers on day 1 and day 7;
3. Apgar Score, oxygen saturation and heart rate in first 20 minutes after birth.
Intervention
Preterm infants are resuscitated with different oxygen concentrations at birth.
c/o room SP-3433
D. Rook
Dr. Molewaterplein 60
Rotterdam 3015 GJ
The Netherlands
+31 (0)10 7037008/ +31 (0)10 7040704
d.rook.1@erasmusmc.nl
c/o room SP-3433
D. Rook
Dr. Molewaterplein 60
Rotterdam 3015 GJ
The Netherlands
+31 (0)10 7037008/ +31 (0)10 7040704
d.rook.1@erasmusmc.nl
Inclusion criteria
Preterm infants with gestational age < 32 weeks.
Exclusion criteria
Known congenital abnormalities, chromosome defects, metabolic disease, and endocrine, renal, or hepatic disorder.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL206 |
| NTR-old | NTR243 |
| Other | : N/A |
| ISRCTN | ISRCTN82896385 |