No registrations found.
Source
Brief title
Health condition
Microbiome (microbioom)
Healthy infant (gezond kind)
Delivery mode (partus)
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Comparison of the composition of infant microbiome between infants born vaginally and infants born by caesarean section at several time points during the first 12 months of life;
2. The dynamics of the infant nasopharyngeal and oral microbiome in periods of respiratory infections.
Secondary outcome
1. The relation between nasopharyngeal, oral, gastrointestinal and skin microbiome;
2. The dynamics of the infant microbiome in periods of antibiotic consumption;
3. Comparison of the composition of the maternal microbiome and the infant microbiome;
4. Comparison of the composition of the infant microbiome between breastfed infants and formula fed infants;
5. The dynamics of the infant microbiome in case of eczema/atopic diseases;
6. The dynamics of the infant microbiome related to exposure (siblings, day care).
Background summary
N/A
Study objective
N/A
Study design
11 home visits during the first year of life and a maximum of 3 extra home visits in case of episodes of respiratory tract infection.
Intervention
Observational prospective cohort study. The development of the infant microbiome during the first 12 months of life and the potential differences in the microbial composition between infants born vaginally and by caesarean section will be studied.
Postbus 770
Astrid Bosch
Hoofddorp 2130 AT
The Netherlands
+31 (0)23 8909070
muis@spaarneziekenhuis.nl
Postbus 770
Astrid Bosch
Hoofddorp 2130 AT
The Netherlands
+31 (0)23 8909070
muis@spaarneziekenhuis.nl
Inclusion criteria
1. Term neonates;
2. Born in the region of Groot Kennemerland and bollenstreek (draining on Spaarne hospital Hoofddorp or Kennemer Gasthuis Haarlem).
Exclusion criteria
1. Severe perinatal/ neonatal/ maternal complications as asphyxia, resuscitation, transfer to neonatal intensive care unit etc;
2. Major congenital anomalies;
3. Language barrier;
4. Intention to move outside the research area;
5. Parents under the age of 18 years.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL3821 |
NTR-old | NTR3986 |
Other | : M012-M015 |
ISRCTN | ISRCTN wordt niet meer aangevraagd. |