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ID
Source
Brief title
Health condition
Parkinson's disease; Freezing of Gait
Sponsors and support
Intervention
Outcome measures
Primary outcome
change in fNIRS activity (i.e. oxygenated hemoglobin and deoxygenated hemoglobin) relative to baseline in 10 regions of interest: the sensorimotor cortex, the supplementary motor area, the premotor cortex, the dorsolateral prefrontal cortex and the posterior parietal cortex (in both hemispheres).
Secondary outcome
Motor scores: gait parameters derived from motion sensors, FOG severity, new FOG questionnaire score, MDS-UPDRS;
Cognitive scores: the MoCA score and Trail Making Test score;
Anxiety scores: the HADS scores and anxiety levels during the walking task.
Background summary
Freezing of gait (FOG) is one of the most debilitating symptoms in Parkinson’s disease (PD). Neuroimaging studies have tried to unravel it’s underlying neural mechanism, but are hampered by severe limitations in study design because subjects need to lay supine and still in scanners. This study proposes to study FOG in real-time by using multichannel functional near-infrared spectroscopy (fNIRS), a mobile neuroimaging technique that has been successfully applied in other gait studies.
Study objective
This is an exploratory brain imaging study, measuring brain oxygenation over 10 regions of interest. Based on the 'cross-talk' hypothesis form Lewis and Barker (2009), we hypothesize that FOG might be associated with increased activity in cognitive cortices (i.e. prefrontal cortex, posterior parietal cortex) and decreased activity in the motor cortices (i.e. sensorimotor cortex, supplementary motor area, premotor cortex) when compared to normal walking.
Study design
Experiment is conducted during a single visit to the laboratory of Nijmegen
Intervention
25 persons with Parkinson's disease OFF anti-Parkinson medication and 25 controls will perform a walking task while brain activity is measured with fNIRS. The walking task includes passages through narrow doorways and 180 degree turns in order to trigger FOG.
Inclusion criteria
- > 18 years old
- idiopathic Parkinson's disease
- experiencing freezing of gait more than once a day
Exclusion criteria
- comorbidities that cause severe gait impairments
- comorbidities that interfere with fNIRS recording (i.e. previous brain surgery, structural cerebral lesions)
- inabilty to comply with the protocol (inability to walk 150 m or make a half turn unaided, inability to walk 10 seconds without experiencing freezing of gait, severe cognitive impairments)
Design
Recruitment
IPD sharing statement
Plan description
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8021 |
| CCMO | NL70915.091.19 |
| OMON | NL-OMON49479 |