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ID
Source
Brief title
Health condition
Respiratory complaints
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study endpoint is the frequency of alterations in treatment of patients with respiratory complaints in the emergency department (ED) based on venous blood gas (VBG) results compared to treatment based on arterial blood gas (ABG) results. We will assess which alterations in treatment occur, the characteristics of alterations and which ABG resuls cause the change.
Secondary outcome
Secondary endpoints are the agreement between venous and arterial pH, bicarbonate, pCO2, lactate and pO2 and the correlation between venous and arterial pO2 and the peripheral oxygen saturation measured with pulse oximetry.
Background summary
An integral part of assessment of patients with respiratory complaints in the emergency department (ED) is determining the acid-base, ventilation and oxygenation status. Traditionally, arterial blood gas (ABG) results have been used. Previous research shows venous blood gas (VBG) results could be a reliable alternative. ABG sampling is often painful, can be challenging to perform, and carries greater risks. The primary objective of this study is to test the hypothesis that treatment of patients with resipratory complaints in the emergency department (ED) based on venous blood gas (VBG) results does not differ from treament based on arterial blood gas (ABG) results. We will assess the frequency of alterations in treatment bases on VBG results compared to treatment based on ABG results. Which alteration intreatment occur, the charesteristics of the alterations and the ABG results causing the change (pH, bicarbonate, pCO2, lactate or pO2) will be assessed.
Study objective
Treatment of patients with respiratory complaints in the emergency department (ED) based on venous blood gas (VBG) results does not differ from treatment based on arterial blood gas (ABG) results.
Study design
Total expected study duration is 6 weeks.
Intervention
One extra blood sample will be obtained with the standard venepuncture or from the peripheral venous catheter to collect the venous blood gas. No extra vascular puncture is required.
Inclusion criteria
Patients (≥ 18 years) presenting in the ED with dyspoea, respiratory rate > 20/min or peripheral oxygen saturation <95%, a reliable saturation measured by pulse oximetry and an indication, determined by the treating physician, to determine the acid-bae, ventilation and oxygenation status by arterial blood gas.
Exclusion criteria
A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Not capable to give informed consent within reasonable time after stabilisation and abating of the accompanying psychological stress, and no representative availabe to give informed consent on behalf of the patient.
- Arterial blood gas results are required for other reasons than determining the acid-base, ventilation and oxygenation status, such as determing the alveolar to arterial oxygen gradiënt (A-a gradient).
- No physician or qualified nurse available for ABG sampling.
- Failed ABG or VBG sampling after two attempts.
- Previous participation in the study.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL8085 |
| Other | METC Zuyd : METCZ20190084 |