No registrations found.
ID
Source
Health condition
hearing loss
tinnitus
tonotopy
auditory cortex
Sponsors and support
Intervention
Outcome measures
Primary outcome
Measures of tonotopic map reorganisation.
Secondary outcome
Relation of hearing loss and degree of reorganisation. Two types of hearing loss are going to be studied: steep-sloping hearing loss and gradual sloping hearing loss.
Background summary
With an increased life expectancy and an ageing population, age-related dysfunctions are becoming more prevalent. The most widespread of all sensory impairments in an ageing population is hearing loss, which is characterized by a loss of sensitivity of the peripheral hearing organ, the inner ear. This peripheral hearing loss is associated with less sensory input available to the brain. Animal research has shown that peripheral hearing loss may cause widespread plastic changes in the brain. Peripheral hearing loss is often associated with tinnitus: about 30% of the people with hearing loss also develop tinnitus. It has been suggested previously that tinnitus and tonotopic reorganisation are causally related. Such cortical reorganisation presumably contributes to the impaired communication skills experienced by humans with hearing loss. With an increasing demand for active participation of the elderly in society, it is crucially important to understand the neurobiological consequences of hearing loss and tinnitus.
The current study employs functional magnetic resonance imaging (fMRI) to investigate the relation between peripheral hearing loss, tinnitus and cortical reorganization. In particular, it aims to map the topographic representation of sound frequency, referred to as tonotopic maps, and how these change as a consequence of tinnitus and hearing loss. It also aims to investigate whether the type of hearing loss is related to the degree of reorganisation.
Study design
No longitudinal design; just one time-point
Intervention
fMRI measurements while listing to sound fragments.
Faculteit Medische Wetenschappen/UMCG, Keel- Neus- en Oorheelkunde
Hanzeplein 1
Groningen 9713 GZ
The Netherlands
050 363 5111
c.p.lanting@umcg.nl
Faculteit Medische Wetenschappen/UMCG, Keel- Neus- en Oorheelkunde
Hanzeplein 1
Groningen 9713 GZ
The Netherlands
050 363 5111
c.p.lanting@umcg.nl
Inclusion criteria
- No hearing loss or reported tinnitus (controls, n=40)
- Hearing loss (Hearing loss group, n=40)
- Tinnitus (Hearing loss and tinnitus group, n=40)
- < 30 dB difference between both ears for all the standard audiometric frequencies
- Adults (18 - 75 yrs.)
- No contraindications for MRI
Exclusion criteria
Non-compliance with inclusion criteria
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL4642 |
NTR-old | NTR4811 |
CCMO | NL44470.042.13 |
OMON | NL-OMON40455 |