No registrations found.
ID
Source
Brief title
Health condition
endocarditis
diagnosis and monitoring of endocarditis
molecular diagnostics
bacterial load
real time pcr
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Determination of the diagnostic value of mBL for the diagnosis of bacterial endocarditis with endocarditis defined according to Duke criteria;
2. Prognostic value of mBL in patients with endocarditis according to Duke criteria with regard to the occurrence of a complicated course;
3. A descriptive model of the kinetics of mBL related to infectious parameters (CRP, WBC, PCT) in patients with an uncomplicated treatment course of bacterial endocarditis.
Secondary outcome
1. Determination of the diagnostic value of mBL for the diagnosis of bacterial endocarditis compared to blood culture results and laboratory markers (e.g. CRP, procalcitonin, WBC);
2. Prognostic value of mBL in patients with endocarditis according to Duke criteria with regard to other outcome parameters (mortality, surgery);
3. Correlation of mBL at start of therapy with clinical severity scores (PITT bacteremia score, APACHE II score);
4. Correlation of mBL at start of therapy with the occurrence of a complicated treatment course at a later time point.
Background summary
N/A
Study objective
The molecular detection of the bacterial load is useful for diagnostics and therapeutic monitoring in patients with (suspected) bacterial endocarditis.
Study design
N/A
Intervention
No interventions; observational study.
Department of Medical Microbiology and Infection Control<br>
Van der Boechorststraat 7
M. Brand, van den
Amsterdam 1081 BT
The Netherlands
+31 (0)20 4448679
marre.vandenbrand@vumc.nl
Department of Medical Microbiology and Infection Control<br>
Van der Boechorststraat 7
M. Brand, van den
Amsterdam 1081 BT
The Netherlands
+31 (0)20 4448679
marre.vandenbrand@vumc.nl
Inclusion criteria
1. Adult patients (≥18 years) with suspected endocarditis, admitted in one of the participating hospitals;
2. Written informed consent is obtained.
Exclusion criteria
1. Failure to obtain written informed consent to participate;
2. Endocarditis caused by Coxiella burnetii (Q-fever);
3. An Hb below 5.0 mmol/L;
4. Death before first sample is obtained.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2790 |
| NTR-old | NTR2930 |
| CCMO | NL35425.029.11 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON35768 |