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ID
Source
Brief title
Health condition
Slowly progressive neuromuscular diseases
Sponsors and support
Intervention
Outcome measures
Primary outcome
Validity of statistical model to determine the anaerobic threshold out of easy to measure indirect variables (heart rate variability, rating of perceived exertion, Talk Test, age, gender, resting heart rate)
Secondary outcome
- The percentage of times that the AT can be determined through submaximal exercise testing with respiratory gas analysis
- The test-retest reliability of the heart rate at the anaerobic threshold determined through submaximal exercise testing with respiratory gas analysis
Background summary
The anaerobic threshold (AT), a submaximal direct marker of aerobic fitness, is used for exercise intensity prescription in the healthy population and other chronic diseases, and may also be useful in NMD. The AT is used as an intensity target which distinguishes between low- and high intensity exercise zones, enabling individuals to exercise in tailored heart rate zones. However, the feasibility and reliability of the AT assessment through submaximal exercise testing in slowly progressive NMDs is not yet known. Further, a major disadvantage of conventional assessment of the AT is that it is a complex and lengthy procedure requiring expensive respiratory gas analysis equipment, and is not readily available in all healthcare settings. Therefore, the next innovative step is to develop a predictive model to easily determine the AT in NMD, i.e. without the use of expensive gas analysis equipment.
The study objective is (1) to determine whether the AT can be identified in individuals with slowly progressive NMD through submaximal exercise testing with respiratory gas analysis, (2) to determine the reliability of the AT assessment in individuals with slowly progressive NMD through submaximal exercise testing with respiratory gas analysis, and (3) to develop a predictive model using easy to measure variables to indirectly assess the AT through submaximal exercise testing without respiratory gas analysis in individuals with slowly progressive NMD.
Study objective
We hypothesize that the assessment of the anaerobic threshold through submaximal exercise testing is feasible and reliable in NMD. Furthermore, we hypothesize that we will be able to develop a valid predictive model to determine the anaerobic threshold using indirect, easy to measure variables.
Study design
Participants will complete three testing days, separated by a minimum of three days. On the first and second testing day, two submaximal exercise tests will be performed, one with and one without respiratory gas analysis. On the third testing day, a maximal exercise test with respiratory gas analysis will be performed.
Intervention
None
Inclusion criteria
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
- presence of slowly progressive NMD.
- ability to perform a maximal exercise test on an arm or bicycle ergometer.
- minimum age of 18 years.
Exclusion criteria
A potential subject who meets any of the following criteria will be excluded from participation in this study:
- absolute contraindication for exercise (based on the guidelines by the American College of Sports Medicine)
- unable to follow verbal or written instructions.
- insufficient mastery of the Dutch or English language.
Design
Recruitment
IPD sharing statement
Plan description
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL9362 |
| Other | METC AMC : METC 2020_236 |