No registrations found.
ID
Source
Brief title
Health condition
Parkinson's disease, glucose and lipid metabolism disorders
Sponsors and support
Intervention
Outcome measures
Primary outcome
Glucose metabolism and lipid metabolism.
Secondary outcome
Hormones.
Background summary
Bilateral subthalamic nucleus deep brain stimulation gives rise to local changes in the brain with a subsequent effect on hepatic triglyceride secretion and endogenous glucose production. By turning the stimulator on and off, insight will be given in the effect on the metabolism.
Study objective
Bilateral subthalamic nucleus deep brain stimulation gives rise to local changes in the brain with a subsequent effect on hepatic triglyceride secretion and endogenous glucose production.
Study design
Start 1-1-2009.
Intervention
2 study days which take 8 hours each. Blood withdrawal every hour during 8 hours and within those hours we also perform a hyperinsulinemic euglycemic clamp.
Academic Medical Center Amsterdam
Amsterdam
The Netherlands
+31 (0)205669111
b.m.sondermeijer@amc.uva.nl
Academic Medical Center Amsterdam
Amsterdam
The Netherlands
+31 (0)205669111
b.m.sondermeijer@amc.uva.nl
Inclusion criteria
Patients with parkinsons disease with bilateral subthalamic nucleus deep brain stimulation.
Exclusion criteria
1. Below 18;
2. Psychiatric disorders;
3. Dyslipidemia;
4. Diabetes.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1657 |
| NTR-old | NTR1754 |
| Other | AMC : METC 08/278 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |