No registrations found.
ID
Source
Health condition
breath, exhaled air, VOC (volatile organic compound), lipid metabolism, fat
Sponsors and support
Intervention
Outcome measures
Primary outcome
postprandial change in VOCs (volatile organic compounds) in exhaled air
Secondary outcome
-
Background summary
Exhaled air contains large numbers of volatile organic compounds (VOCs) that may be derived from the body's internal metabolism. The main ovjective of this study is to investigate whether it is possible to use VOCs in exhaled air as a parameter of lipid metabolism.
Study objective
Currently, the effects of nutrition or specific food components, including those on absorption or metabolism, are mostly studied via parameters in blood samples. To reduce the burden for participants of nutritional intervention studies, there is a high need for non-invasive methods. Exhaled air contains large numbers of volatile organic compounds (VOCs) that may be derived from the body's internal metabolism. So this might be an interesting, non-invasive parameter.
Study design
various measurements for 5 hours postprandial
Intervention
low-fat milk (0.1% fat) vs high-fat milk (10% fat)
Inclusion criteria
- Caucasian male
- 18-35 years old
- Body mass index between 22-25 kg/m2
- Fat percentage between 8-15%
- Regular consumption of milk (products)
Exclusion criteria
- (symptoms of) cow's milk allergy
- lactose intolerance
- metabolic diseases
- (known symptoms of) (auto)immune diseases, like diabetes
- (known symptoms of) intestinal diseases, like: irritable bowel syndrome, intestinal malabsorption, diagnosed with celiac disease, Chron's disease, coliltis ulcerosa, short bowel syndrome or surgical bowel interventions leading to malabsorption
- usage of medication
- usage or hard drugs
- history of smoking
- claustrophobia
- unsuitable veins for blood sampling
- blood donation during the two months before the start of the study
- current participation in other scientific studies
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5819 |
| NTR-old | NTR5974 |
| Other | METC WUR : 16/05 |