No registrations found.
ID
Source
Brief title
Health condition
1. Beta-glucan;
2. healthy subjects;
3. gastric emptying;
4. postprandial blood glucose.
Sponsors and support
Intervention
Outcome measures
Primary outcome
The ß-glucan effect on the rate of gastric emptying was statistically not significant compared with cornflakes. Consumption of ß-glucan lowered the postprandial glucose response significant (p<0.05).
Secondary outcome
The effect of ß-glucan on satiety was not statistically significant.
Background summary
World wide the incidence of type 2 diabetes mellitus is increasing rapidly. To prevent development of diabetes mellitus it is recommended by the American Diabetes Association to consume dietary fiber food. Products enriched with â-glucan have been shown to reduce postprandial glucose and insulinemic responses in healthy subjects and in type 2 diabetes patients. Gastric emptying, among other factors, regulates the postprandial blood glucose response, and a delay in gastric emptying rate leads to a lower postprandial blood glucose response. Delayed gastric emptying occurs in 30-50 % of diabetes patients. This is an important issue that should be evaluated because of the nutrition recommendations with an increased intake of fiber and a high prevalence of delayed gastric emptying among diabetes patients. Patients with diabetes are recommended to consume commercial products with fibre to control the blood glucose levels. However, commercial products have not been properly evaluated regarding postprandial blood-glucose levels and gastric emptying.
The result of this randomized crossover blinded study demonstrates that intake of commercial breakfast cereals with fiber affects gastric emptying without reducing the postprandial blood glucose in the same extent and can therefore not bee recommended to be consumed to control the blood glucose levels.
Study objective
The aim of this study was to evaluate the effect of ß-glucan on the rate of gastric emptying, postprandial glucose response and satiety in healthy subjects.
Study design
N/A
Intervention
Twelve healthy subjects were assessed using a randomized crossover blinded trial. The subjects were examined after an 8 hours fast and assessment of normal fasting blood glucose level. Gastric emptying rate was calculated as the percentage change in the antral cross-sectional area 15 and 90 minutes after ingestion of vanilla yoghurt with flakes containing 4 g beta-glucan (GER1) or vanilla yoghurt with Kellogg´s cornflakes (GER2). Significant differences were evaluated with Wilcoxon t-test.
Joanna Hlebowicz
Malmö 205 02
Sweden
+46-40-331000
Joanna.Hlebowicz@skane.se
Joanna Hlebowicz
Malmö 205 02
Sweden
+46-40-331000
Joanna.Hlebowicz@skane.se
Inclusion criteria
Helthy subjects without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus were included in the study.
Exclusion criteria
1. Diabetes mellitus;
2. prior abdominal surgery;
3. symtoms of gastrointestinal disease;
4. Obesity.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL946 |
| NTR-old | NTR971 |
| Other | : |
| ISRCTN | ISRCTN90535566 |