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ID
Source
Brief title
Health condition
All patients ≥ 18 years admitted to the adult Intensive Care Unit.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Our objective is to quantify international transfusion practice in ICUs. We will be looking at transfusion and administration of RBCs, platelets, plasma and several coagulation agents (pro-coagulant and anti-fibrinolytic) in correlation to clinical parameters and corresponding laboratory values. Differences within and between regions will be studied.
Secondary outcome
Secondary objectives will include the following:
- To evaluate the effect of physiological triggers on transfusion practice;
- To evaluate the effect of transfusion on corresponding hematology laboratory variables;
- To compare transfusion practice in different patient subgroups, e.g. septic shock and coronary disease;
- To evaluate the association of transfusion thresholds applied and clinical outcomes (e.g. 28-day mortality).
Background summary
It has been known that the variance in transfusion practice in intensive care units (ICUs) is high worldwide. However, current studies are limited among others by focusing on one blood product or one country’s practice. This point prevalence study aims to describe transfusion practice in an observational point prevalence design in ICUs worldwide. Moreover, we aim to describe the physiological triggers and clinician’s motivation for transfusion.
Study objective
We expect to find a large heterogeneity in transfusion practice (i.e. thresholds and motivation for transfusion) in ICUs worldwide.
Study design
Each center signs up for an inclusion week. In every inclusion week, for every newly admitted patient of >18 years and older, several questionnaires need to be filled in:
- Baseline demographics;
- Daily questionnaire up to 28 days or ICU discharge, whatever comes first;
- Outcome questionnaire;
- For every transfusion a separate transfusion questionnaire.
Inclusion criteria
Patients are included in the study if they are aged 18 years and older and are newly admitted to the ICU during the course of a pre-specified week (7 days).
Exclusion criteria
All patients younger than 18 years old
No informed consent in countries where no opt-out procedure applies.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9049 |
| Other | METC AMC : W18_290#18.449 |