No registrations found.
ID
Source
Brief title
Health condition
longstanding UC
Sponsors and support
Intervention
Outcome measures
Primary outcome
Number of patients with detected neoplasia.
Secondary outcome
1. Number of neoplastic lesions;
2. Pit pattern classification (Kudo) of neoplastic lesions;
3. Vascular pattern description of neoplastic lesions.
Background summary
Patients with longstanding UC will undergo colonoscopic surveillance by both WLE and NBI with a time interval of at least 4 weeks between the procedures. Randomization determines the order of the two techniques. During both procedures targeted biopsies will be taken from suspicious lesions. Only during the second procedure additional random biopsies will be taken according to current clinical guidelines. All detected lesions will be inspected and imaged with NBI and the mucosal morphology and vascular pattern will be classified. The histopathological outcome of the biopsies will be used as the gold standard for diagnosis.
Study objective
Aim: to compare narrow band imaging (NBI) and standard white light endoscopy (WLE) for the detection of neoplasia during colonoscopic surveillance of patients with longstanding ulcerative colitis (UC).
Intervention
NBI-Colonoscopy and WLE-colonoscopy.
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Inclusion criteria
1. Objective diagnosis of UC (histologically and/or endoscopically);
2. Extensive UC (proximal to splenic flexure);
3. Disease duration > 8 years;
4. Inactive disease (Truelove Witts Index<2);
5. Informed consent.
Exclusion criteria
1. Age < 18 years;
2. Non correctable coagulopathy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL839 |
| NTR-old | NTR853 |
| Other | : N/A |
| ISRCTN | ISRCTN56671833 |