No registrations found.
ID
Source
Brief title
Health condition
Adopting or maintaining a physically active lifestyle is often not feasible for statin users, as muscle toxicity is the most frequent adverse effect of statins. In multiple studies it is suggested that muscle mitochondria are affected in statin users with muscle complaints. However, it is currently unknown if the exercise intolerance of statin users with muscle complaints is causally related to disturbances in muscle mitochondrial function.
Key words: statins, physically active lifestyle, exercise intolerance, muscle toxicity, mitochondrial function.
Kernwoorden: statines, fysiek actieve leefstijl, inspanningsintolerantie, spierklachten, mitochondriale functie.
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Exercise-induced change in aerobic fitness
- Exercise-induced change in mitochondrial mass and function and substrate use
Secondary outcome
- Exercise-induced change in muscle strength, contractile function and fatigue, and muscle mass
- Exercise-induced change in pain- and fatigue rating, and quality of life
Study objective
We hypothesize that improving both the quantity and quality of the mitochondria by exercise training may counteract the statin-induced myocellular changes, and optimize muscle function and overall exercise capacity.
Study design
All measurements are performed before exercise training and after 12 weeks of exercise training.
Intervention
Combined endurance and resistance training program
Eline Allard
Nijmegen
The Netherlands
024-3614906
eline.allard@radboudumc.nl
Eline Allard
Nijmegen
The Netherlands
024-3614906
eline.allard@radboudumc.nl
Inclusion criteria
3 study groups:
1. Statin users with self-reported muscle symptoms
2. Statin users without muscle symptoms or other side effects
3. A control group, not using any statins
Inclusion criteria
- Males and females aged 40 to 70 years.
- Mentally able to give informed consent.
- Current statin user (group 1-2) for at least 3 months
Exclusion criteria
- Familial hypercholesterolemia
- History of cardiovascular event within 1 year of study participation
- Known hereditary muscle defect
- Known mitochondrial disease
- Diabetes Mellitus
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5972 |
| NTR-old | NTR6346 |
| Other | NL59192.091.16 : 2016-2867 |