No registrations found.
ID
Source
Brief title
Health condition
Cardiac output
Nexfin
General anesthesia
Day case sugery
Fluid expansion
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cardiac output before and after fluid expansion.
Secondary outcome
1. Blood pressure before and after fluid expansion;
2. Use of vasoactive medication.
Background summary
Fluid expansion is considered the primary intervention in case of hypotension during general anesthesia. The aim of this study is to determine the efficacy of fluid expansion in the treatment of hyotension during day case surgery in patients under general anesthesia without significant blood loss. Fluid expansion of 6 ml/kg ideal weight is administered in case of hypotension, defined as systolic blood pressure < 90 mHg or a decrease in mean arterial pressure of > 25%. The effect of fluid expansion on cardiac output and blood pressure is measured using Nexfin, a non-invasive continuous cardiac output monitor.
Study objective
Perioperative fluid expansion as primairy treatment of hypotension in day case surgery leads to a modest increase of cardiac output.
Study design
T0= Before start of fluid expansion;
T1= 5 minutes after completion of fluid expansion;
T2= 20 minutes after fluid expansion;
T3=30 minutes after fluid expansion.
Intervention
Fluid expansion of 6 ml/kg ideal weight in case of hypotension, defined as systolic blood pressure < 90 mHg or a decrease in mean arterial pressure of > 25%.
Charlotte Hofhuizen
Nijmegen 6525 GA
The Netherlands
+31 (0)24 3614406
c.hofhuizen@anes.umcn.nl
Charlotte Hofhuizen
Nijmegen 6525 GA
The Netherlands
+31 (0)24 3614406
c.hofhuizen@anes.umcn.nl
Inclusion criteria
1. Patients under general anesthesia in minor day case sugery;
2. ASA classification I and II.
Exclusion criteria
1. Age < 18 years;
2. Duration of surgery > 240 minutes;
3. Digital ischaemia;
4. Preexisting cardiac arrhythmias;
5. Expected blood loss > 300 ml
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3500 |
| NTR-old | NTR3677 |
| Other | CMO Regio Arnhem-Nijmegen : 2012/353 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |