No registrations found.
ID
Source
Brief title
Health condition
Congenital CMV infection
Sponsors and support
Intervention
Outcome measures
Primary outcome
Diagnostic accuracy of in utero MRI in case of congenital CMV
Secondary outcome
Diagnostic agreement between antenatal US and in utero MRI in case of congenital CMV
Background summary
The aim of the study is to improve the prenatal counselling of parents and to guide future management decisions in cases of proven cCMV infection. In particular the emphasis is on the additional contribution made by in utero MRI relative to the information already established by antenatal ultrasound, timing of CMV infection. In order to achieve this, the following measures will be analysed:
- Comparison of the diagnostic agreement between antenatal ultrasound and in utero MRI
- Quantification of the diagnostic accuracy of MRI in cases of proven cCMV infection (with reference to clinical and pathological outcome)
- Correlation of MRI findings with clinical outcome.
- Comparison between the first MRI diagnosis at the first center and the second look by a trained fetal MRI specialist.
Study objective
Fetal MRI can be helpfull in detecting CMV related lesions and can help in this way the counseling of patients in the future.
Study design
1 MRI during pregnancy
at least 1 clinical follow up postnataland/or autopsy findings.
Intervention
second look fetal MRI + correlation postnatal follow up
Inclusion criteria
- CMV seroconversion during pregnancy
- CMV positive amniotic fluid or/and CMV positive urine neonate.
Exclusion criteria
- No signs of CMV in amniotic fluid or/and positive urine neonate.
- no postnatale follow up.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3990 |
| NTR-old | NTR4162 |
| Other | : Mieke Cannie |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |