No registrations found.
ID
Source
Health condition
executive functions
self-report
informant-report
neuropsychological testing
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are several measurements of executive functioning obtained via neuropsychological testing, a self-report questionnaire and an informant-report questionnaire. Possible cognitive profiles will be compared between the elderly with and without autism.
Secondary outcome
No secondary outcome
Study objective
The current study will provide a comparison between elderly with ASD with matched non-patient controls on various EF tasks to determine which cognitive defects are present in elderly. Only a few studies exist on which we can base a hypothesis, but we expect eledery ASD patients to be characterised by deficits in working memory and fluency.
We will compare neuropsychological findings with a measurement of self-report and informant report. Earlier research indicates that including additional measurements of EF will increase the ecological validity and will thus provide more solid ground to generalize clinical data to everyday life. Self-report is expected to have little to no correlation with neuropsychological testing because previous research has suggested that self-report of cognitive ability is only weakly, if at all, related to test performance in neurological populations (Burgess, Alderman, Evans, Emslie, & Allinson, 1998; Evans, Chua, Mckenna, & Wilson, 1997; Goldstein & McCue, 1995; Kaitaro, Koskinen & Kaipio, 1995; Sunderland, Harris, & Baddeley, 1983). It is expected that informant report will correlate with neuropsychological tests (Burgess, Alderman, Evans, Emslie, & Allinson, 1998). We will also make recommendations for the clinical field based on our results.
Study design
No timepoints
Intervention
A series of neuropsychological tests, a self-report questionnaire and an informant report questionnaire
Inclusion criteria
-Male
-Age above 60
-An autism Spectrum Disorder as described in the DSM-5
-Intelligence within the normal range, or above. Total, verbal and performal IQ above 85. This is based on the IQ-cutoff provided by the DSM-IV-TR (V-code V62.89) which indicates mental impairment below 85.
Exclusion criteria
General exclusion criteria:
-Specific somatic disorders: Active infection, known genetic abnormalities, metabolic disorder, tuberculosis, epilepsy and traumatic brain injury.
- Cases with disturbance of consciousness, delirium, psychosis, suicidal tendencies, severe aphasia, or major sensorimotor impairment precluding neuropsychological testing.
-Substance abuse (current)
Additional exclusion criteria for the non-ASD comparison group:
-Participant doesn’t have an Autism Spectrum Disorder, or any other current psychiatric diagnosis.
-First degree family member with an Autism Spectrum Disorder, or any other current psychiatric diagnosis.
Note: Both criteria will be ascertained by the use of a standardized checklist. A qualified clinician will oversee the testing procedure and verify (if possible) with clinical experience.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4559 |
| NTR-old | NTR4702 |
| CCMO | NL45575.008.13 |
| OMON | NL-OMON40217 |