No registrations found.
ID
Source
Brief title
Health condition
Acute myocardial infarction
Sponsors and support
Intervention
Outcome measures
Primary outcome
To investigate the incidence of DOA use in patients between 18 and 45 years old presenting at the emergency department (ED or coronary care unit (CCU) at the participating hospitals with AMI.
Secondary outcome
-To evaluate which DOA are prevalent in young patients with AMI
-To investigate the difference in other cardiac risk-factors and risk-stratification scores in the DOA versus no-DOA group
-To investigate the difference in significant atherosclerotic CAD in the DOA versus no-DOA group
-To investigate the difference in length of hospital stay in the DOA versus no-DOA group
-To investigate the difference in major adverse cardiac events (MACE) in the DOA versus no-DOA group
Background summary
Rationale: Little is known about the risk for manifestations of cardiac ischemia due to Drugs Of Abuse (DOA). The strong correlation between cocaine and Acute Myocardial Infarction (AMI) at a young age is well studied. However, the relation between cardiac ischemia and other DOA remains unclear.
Objective: The aim of this study is to evaluate the incidence of DOA use in young adults aged 18-45 years old, diagnosed with an Acute Myocardial Infarction.
Study design: Multicenter exploratory cohort study
Study population: Adults aged18 till 45 years old diagnosed with AMI (all subtypes) in the Emergency Department (ED) or Coronary Care Unit (CCU) of the OLVG hospital and the Amsterdam UMC in Amsterdam, the Netherlands.
Intervention: No interventions are performed
Main study parameters/endpoints: The main endpoint is the number of patients and type of DOA that patients with AMI test positive for using the Toxtyper test.
Nature and extent of the burden and risks associated with participation, benefit and group relatedness: There is no risk or burden for participants as no extra interventions are performed. An extra blood sample is collected for Toxtyper testing during routine blood tests that are taken within common practice for treating AMI.
Study objective
25% of AMI in patients >17 and <45 years old have a positive toxtyper screening for recreational drug use
Study design
Start 1 march 2020
Intervention
none
Inclusion criteria
• Age >17 and <46 years old
• Diagnosed with AMI according to ESC protocol
Exclusion criteria
• Start of symptoms of ACS >48hr prior to inclusion
• No informed consent obtained
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8112 |
| Other | MECU : R19.076 |