No registrations found.
ID
Source
Brief title
Health condition
Cardiopulmonary bypass, perfusion monitor, cardiovascular patients, adequate oxygen delivery, hypo-perfusion, hyper perfusion, postoperative complications, individual circulatory treatment.
Sponsors and support
Laarbeeklaan 101
1090 Jette
Laarbeeklaan 101
1090 Jette
Intervention
Outcome measures
Primary outcome
Which oxygen flow gives hyperlactatemia?
Secondary outcome
Evaluation of kidney function.
Background summary
Adequate oxygen delivery (D02) to the organs and tissues of the cardiovascular patient is the primary principle of putting patients on cardiopulmonary bypass (CPB). The golden standard for calculation of flow is 2,4 L/min/m2 body surface area (BSA). Blood flow during CPB is standardized worldwide; i.e. 2,2-2,5 LPM/m2. There is an increasing tendency towards a more individual circulatory treatment. In fact, individualized goal-directed therapy has been shown to reduce postoperative complications and mortality in high-risk surgery.
Hypo-perfusion (defined as the inadequate delivery of oxygen) and the resulting Hyperlactatemia are well described and quantified, as well as their postoperative consequences. The effects of hyper-perfusion are far less investigated.
A new perfusion monitor is developed to continuously monitor, in real-time and online, the different determinants of oxygen delivery and oxygen consumption of the patient.
Study objective
Evaluation of the golden standard in perfusion by using a perfusion monitor to evaluate adequate oxygen delivery.
Study design
1) Blood gas before cardiopulmonary bypass(CPB), after 10', 30', 60', 90', 120' and post CPB.
2) Postoperative we will also look at the highest lactate level during hospital stay.
Intervention
Arterial and venous connector for inline measurement. Regular blood gas analysis. Blood flow sensor measurement.
Veerle Mossevelde, van
Brussels 1090
The Netherlands
+32 (0)2 4763134
veerle.vanmossevelde@uzbrussel.be
Veerle Mossevelde, van
Brussels 1090
The Netherlands
+32 (0)2 4763134
veerle.vanmossevelde@uzbrussel.be
Inclusion criteria
-Patients scheduled for cardiac surgery.
-Normothermic cases and maximum duration less than 2 hours.
Exclusion criteria
-Complicated cases
-CPB duration over 2 hours
-renal insufficiency
-emergency
-reanimation
-salvage and existing inflammatory conditions.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4399 |
| NTR-old | NTR4596 |
| Other | MEC UZ Brussel : 2014/017 |