No registrations found.
ID
Source
Brief title
Health condition
colorectal cancer, precursor lesions, adenoma, flat, non-polypoid, high-risk population, family history of colorectal cancer
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Prevalence of flat colorectal lesions in a Dutch population;
2. Clinical characteristics (e.g. location of lesions, percentage of high-grade dysplasia or early cancer);
3. Molecular charcteristics (epigenetic: methylation status and genetic) of flat vs. polypoid colorectal lesions;
4. Prevalence of flat advanced colorectal cancers vs. polypoid advanced colorecal cancers: clinical features of these lesions (e.g. tumor stage);
5. Relation between serrated and adenomatous polyps.
Secondary outcome
Prevalence and genotype and fenotype associations of flat colorectal lesions in patients at high-risk for colorectal cancer.
Background summary
N/A
Study objective
1. Flat adenomas are common findings in patients at average- or at high-risk for CRC;
2. Flat adenomas are characterized by a different molecular profile as compared to polypoid lesions; these molecular features are associated with an increased risk for progression to CRC;
3. Serrated polyps are common findings in a population attending for routine colonoscopy.
Study design
Analysis will be performed after the colonoscopy.
Intervention
1. Clinical data registration;
2. Molecular analysis of polypoid vs. flat colorectal lesions.
E. Rondagh
Department of Gastroenterology and Hepatology
Maastricht University Medical Center
Maastricht 6202 AZ
The Netherlands
+31-43-3875021
Eveline.Rondagh@INTMED.unimaas.nl
E. Rondagh
Department of Gastroenterology and Hepatology
Maastricht University Medical Center
Maastricht 6202 AZ
The Netherlands
+31-43-3875021
Eveline.Rondagh@INTMED.unimaas.nl
Inclusion criteria
Patients referred for routine colonoscopy with or without positive familiy history for colorectal cancer.
Exclusion criteria
Molecular analysis: patients with inflammatory bowel disease.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1781 |
| NTR-old | NTR1891 |
| Other | Metc - Maastricht University Medical Center : MEC 08-4-074 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |